Abstract: Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with ⁹⁹Tc^mlabeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.