2015 Vol. 39, No. 2
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2015, 39(2): 105-109.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.001
[PDF 837KB]
Abstract:
Objective To give target outline guidance for lung tumor radiation therapy by respiratory gating(RG) four-dimensional PET/CT for lung cancer. Eventually reasonable radiation target regions in treatment planning are received by patients. Methods Twenty malignant nodules were studied by RG PET/CT and conventional PET/CT. The differences of gross tumor volume defined by average four-dimensional PET and three-dimensional PET were compared in different lung locations. Differences of gross tumor volume defined by average four-dimensional CT and three-dimensional CT were also investigated. Differences between volume defined by average four-dimensional volumes and three-dimensional volumes were defined as relative difference of gross tumor volume, and influences for volume defined by four-dimensional PET and CT and three-dimensional PET and CT based on the nodal position and respiratory motion amplitude were also investigated in this study. Results Both volumes defined by average four-dimensional PET measured with two techniques were 17.2% greater than the volume defined by three-dimensional PET on average. The relative difference of the volume defined by average four-dimensional PET and three-dimensional PET was related to the nodal position and respiratory motion amplitude. The mean difference was 26.5% for the lower lobe and hilus of the lung, which was much greater than that of the upper lobe and pleura(2.7%). When the respiratory motion amplitude of nodules was > 3 mm, the difference between the volumes defined by average four-dimensional PET and three-dimensional PET was 24.3%(as < 3 mm, difference was 1.8%). The volume defined by average four-dimensional CT was 3.9% larger than the volume defined by three-dimensional CT, with difference range of nodule volume at 0.2 cm3 to 5.9 cm3 and ratios of 1.10±0.32. Only the nodules in the lower lobe showed significantly larger volumes defined by average four-dimensional CT than those defined by three-dimensional CT with average difference of 11.3%. Conclusion For lung nodules close to the liver and spleen, the volume defined by average four-dimensional PET showed more accuracy for sketching tumor target. For nodules around the hilus of the lung, the volume defined by average four-dimensional PET can be considered as tumor target. For the upper lobe and pleural nodules, the volume defined by average four-dimensional CT was selected for the target outline, which adopted low-dose RG scan and considered breathing movement.
2015, 39(2): 110-115.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.002
Abstract:
Objective To explore the values of preoperative serum thyroid stimulating hormone, thyroglobulin and antithyroglobulin antibody in predicting the risk of differentiated thyroid carcinoma. Methods 122 patients with thyroid nodules who got operations were studied, among which 55 patients with differentiated thyroid carcinoma(54 papillary and 1 follicular), 67 cases with benign thyroid nodules(40 nodular goiter and 27 adenoma). Serum thyroid-stimulating hormone(TSH) and thyroglobulin(Tg)were measured by chemiluminescence method, and antithyroglobulin antibody(TgAb) by radioimmunoassay. Thyroid tissues and cervical lymph nodes were checked using color doppler ultrasonic diagnostic instrument and the postoperative pathological results was regard as the gold standard of diagnosing thyroid cancer. Results Preoperative serum Tg levels in thyroid cancer group(24.09±64.59)ng/ml and benign thyroid nodules group(23.37±112.14) ng/ml had no statistical differences(Z=1.092, P > 0.05). TSH levels in thyroid carcinoma group(2.32±2.28) mIU/L were higher than that in benign thyroid nodules group(1.75±1.22) mIU/L(Z=2.107, P < 0.05). The positive rate of Tg combined with TgAb in thyroid cancer group(72.7%) was higher than that in benign thyroid nodules group(55.2%)(χ2= 3.975, P < 0.05). Receiver operating characteristic(ROC) curves showing sensitivity as a function of specificity were calculated for TSH, Tg levels and TSH : Tg values to evaluate the potential accuracy of the three index as predicting differentiated thyroid carcinoma. The area under the curve(AUC) of TSH was 0.611[95% confidence interval(95% CI):0.509~0.713], P < 0.05. The optimum threshold in ROC curves of TSH was 2.31 mIU/L. The sensitivity and specificity of TSH were 71.6% and 50.9% respectively. The AUC of TSH : Tg values was 0.617(95% CI:0.518~0.716), P < 0.05. The best critical value of TSH : Tg was 0.11 IU/mg. The sensitivity and specificity of TSH : Tg were 61.2% and 50.9% respectively. The AUC of Tg was less than 0.5. Conclusion Serum thyroglobulin elevated abnormally is not an independent predicting factor of differentiated thyroid cancer. The elevated Tg levels and/or positive TgAb and TSH : Tg > 0.11 IU/mg can be used as effective supplementary means of ultrasound examination in predicting differentiated thyroid carcinoma.
2015, 39(2): 116-120.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.003
Abstract:
Objective To analyze the metabolic process-related genes and pathway variations in the c-kit(CD117, a cytokine receptor expressed on the surface of hematopoietic stem cells)positive cells after 4 Gy irradiation by using gene chip technology. Methods c-kit positive cells were sorted by microbead separation system. Two groups were involved:control group and 4 Gy irradiation group. A total of 1×106 c-kit positive cells received 4 Gy irradiation at a dose rate of 0.99 Gy/min. After the two groups were cultured for 18 h, all the cells were collected and detected by gene chip arrays. Data were processed and analyzed via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Results After 4 Gy γ-ray irradiation, 13 metabolic process-related genes were up-regulated more than 3 times:Pld5, Neu2, Bpgm, Alas2, Satl1, Rdh16, Mccc1, Sat2, Smug1, Cml5, Adhfe1, Idh3a, and Slc27a5. Additionally, 22 genes were down-regulated more than 3 times:Acss2, Phgdh, Psat1, Glb1, Gpam, Dus3l, Fuca2, Impdh1, Dlat, Glb1, Enpp4, Prim2, Mettl10, Slc27a2, Dera, Qdpr, Dus1l, Cdyl2, Dhodh, Srr, Spr, and Mical2. These genes were involved in pyrimidine metabolism, purine metabolism, and citrate cycle(TCA cycle) pathways. Conclusion Many variations of genes and pathways in c-kit positive cells existed after 4 Gy irradiation. However, further laboratory technology is required to confirm these variations.
2015, 39(2): 121-123.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.004
Abstract:
Objective To investigate the protective activity of Siwu Decoction against acute radiation injury. Methods The population of peripheral white blood cells(WBCs) and bone marrow nucleated cells, as well as the 30 d survival rate of mice were studied in accordance with the China Food and Drug Administration regulation on anti-radiation health food. Results Compared with the control group, mice treated with Siwu Decoction showed significantly increased peripheral WBCs, red blood cells, hemoglobin, platelets, and bone marrow nucleated cells. The 30 d survival rate increased in all administration groups of mice. Conclusion Siwu Decoction extract at recommended dose exerts protective activity against radiation injury.
2015, 39(2): 124-128.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.005
Abstract:
Objective To compare the accuracies of MRI and 1997 edition of Partin tables in predicting the pathological features of prostate cancer. Methods A total of 51 patients with prostate carcinoma underwent radical prostatectomy from January 2012 to February 2014. Preoperative serum prostate specific antigen, clinical stage, biopsy Gleason score, percentage of positive biopsy scores, pelvic MRI, and pathological report of prostatectomy specimen were collected. Postoperative pathological results were compared with MRI results and Partin tables. Receiver operating characteristic curves were plotted to determine the accuracies of MRI and Partin tables in predicting the pathological features of prostate cancer. Results The areas under the curve(AUCs)of the Partin tables to predict organ-confined disease(OCD), established capsular penetration(ECP), seminal vesicle involvement(SVI), and lymph nodal involvement(LNI) were 0.911, 0.742, 0.827, and 0.899, respectively. The corresponding AUCs of MRI were 0.902, 0.765, 0.563, and 0.5. The AUCs of OCD and ECP did not significantly differ between MRI and Partin tables(Z=0.071 and 0.020, both P > 0.05). By contrast, the AUCs of SVI and LNI significantly differed between MRI and Partin tables(Z=0.286 and 0.499, both P < 0.01). Conclusion Partin tables exhibit a high clinical diagnostic value in the prediction of the pathological feature of prostate cancer. The accuracies of predicting OCD and ECP did not significantly differ between MRI and Partin tables. However, Partin tables were more accurate in predicting SVI and LNI than MRI.
2015, 39(2): 129-135.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.006
Abstract:
Objective To explore the application value of the change ratio of the apparent diffusion coefficient(ΔADC) in the therapeutic evaluation of hepatocellular carcinoma(HCC) treated by single transcatheter arterial chemoembolization(TACE). Methods Forty-eight patients diagnosed with advanced HCC underwent diffusion-weighted imaging, dynamic enhanced MRI, and CT before and one month after TACE. The follow-up data for all selected patients were accumulated, and the disease progression in the follow-up was considered the end point. The progression-free survival of every patient was recorded after TACE. The responses one month after TACE were assessed via digital subtraction angiography, ΔADC, MRI, and CT, of which DSA was considered the "gold standard." The groups were divided into three groups: good, middle, and bad. The PFS curves were then plotted. The consistency of the other three evaluation methods with the "gold standard" was evaluated by kappa test. Results Fifty-six lesions were found in 48 patients according to the DSA results, where 30, 16, and 10 lesions belonged to the good, middle, and bad groups, respectively. The survival curves among the 3 groups were statistically significant(χ2=29.89, P < 0.01), and the median PFSs of the good, middle, and bad groups were 7.5, 4.0, and 1.1 months, respectively. The ΔADC results indicated that the ADC values generally increased after a single TACE; the ΔADC and survival curves among the 3 groups were also statistically significant(χ2=26.57, P < 0.01);the median PFSs for the good, middle, and bad groups were 7.5, 4.6, and 1.8 months, respectively. The kappa test shows that the ΔADC was perfectly consistent with the "gold standard"(kappa=0.542, P < 0.01), but the MRI and CT were poorly consistent with the "gold standard"(Kappa=0.328, 0.260, P < 0.05). Only the MRI was statistically significant(χ2=30.623, P < 0.01) in the survival curve. Conclusion The ΔADC can evaluate the efficacy of TACE timely and objectively, and the ΔADC is clinically significant in guiding the subsequent treatment after a single TACE.
2015, 39(2): 136-139, 143.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.007
Abstract:
Objective To investigate the clinical application value of multislice spiral CT(MSCT) for temporal bone and multiple post-processing reconstruction techniques for infant cochlear implantation. Methods Fifty preoperative patients and two postoperative patients with severe sensorineural hearing loss(SNHL) underwent high-resolution temporal bone MSCT. Double-threshold reconstruction, transparent imaging and three-dimensional fusion, double-oblique diameter multiplanar reconstruction, and curved planar reconstruction were used to measure the distance between the vertical facial nerve and external acoustic canal and the round window breadth, as well as analyze the inner ear structure. Results ① Out of 50 preoperative patients, 7 showed inner ear malformations, 9 presented chronic tympanomastoiditis, and 34 exhibited normal ear structure. The probability of inner ear malformations was 14.0%. Before cochlear implantation, the inner ear structure and ossicular chain were clearly observed in all the patients enrolled in this study. The distance between the vertical facial nerve and external acoustic canal was (0.33±0.057) cm on the right side and(0.33±0.068) cm on the left side. The round window breadth was (0.14±0.027) cm on the right side and(0.14±0.025) cm on the left side. ②The electrodes and postoperative changes were clearly detected in two patients with cochlear implants. Conclusion Inner ear malformations were clearly shown by high-resolution temporal bone scanning in a number of SNHL patients. Multiple post-processing techniques can significantly obtain precise information on the temporal anatomical structure before cochlear implantation and provide accurate assessment of the operation.
2015, 39(2): 140-143.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.008
Abstract:
Objective To explore the effect of additional selenium on the serum levels of thyroid peroxidase antibody(TPOAb) after treatment of Graves disease with 131I. Methods A total of 266 patients with TPOAb levels between 10 and 1300 IU/ml participated in this study. TPOAb levels within 10 IU/ml to 60 IU/ml were considered negative, and levels greater than 60 IU/ml were considered positive. All patients were randomly divided into control(n=112) and selenium treatment group(n=154). After treatment with 131I, the control group received conventional therapy, whereas the selenium treatment group received additional selenium(100 μg twice a day). The TPOAb levels and positive ratios of the two groups were compared with pre-therapy levels after treatment for 6 and 12 months. Results After 6 months, the TPOAb levels in both groups significantly increased compared with the pre-therapy levels(control group:Z=-2.084, P < 0.05; selenium treatment group:Z=-2.112, P < 0.05). However, no significant difference existed in the TPOAb levels between the two groups(Z=-0.764, P > 0.05). After 12 months, the TPOAb levels in the control group did not change significantly compared with the pre-therapy levels(Z=-1.538, P > 0.05), whereas the TPOAb levels in the selenium treatment group significantly decreased compared with the pre-therapy levels(Z=-5.465, P < 0.01). The difference between the two groups were statistically significant(Z=-2.180, P < 0.05). The positive ratios of TPOAb for both groups did not change significantly 6 or 12 months after 131I therapy(control group:x12= 0.720, x22=0.103, both P > 0.05; selenium treatment group:x12=0.023, x22=0.340, both P > 0.05). Overall, the positive ratios were not statistically significant between the two groups(x12=0.001, x22=0.366, both P > 0.05). Conclusion Additional treatment with selenium after 131I therapy for Graves disease can effectively decrease the TPOAb levels, especially for patients with high initial TPOAb levels.
2015, 39(2): 144-148.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.009
Abstract:
Exosomes are small membrane vesicles with a size of 40~100 nm in diameter released ubiquitously by cells. They contain a large amount of microRNAs and proteins and play a critical role in intercellular communication. Tumor cells can release more exosomes than normal cells. These exosomes influence tumor environment by transferring proteins, RNAs, and lipids between cells, thus aiding invasion and metastasis. This paper reviewed the structure characteristics, biogenesis, secretion pathway, and the function of radiation-induced exosomes and discussed its role in tumor invasion and metastasis.
Exosomes are small membrane vesicles with a size of 40~100 nm in diameter released ubiquitously by cells. They contain a large amount of microRNAs and proteins and play a critical role in intercellular communication. Tumor cells can release more exosomes than normal cells. These exosomes influence tumor environment by transferring proteins, RNAs, and lipids between cells, thus aiding invasion and metastasis. This paper reviewed the structure characteristics, biogenesis, secretion pathway, and the function of radiation-induced exosomes and discussed its role in tumor invasion and metastasis.
2015, 39(2): 149-153.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.010
Abstract:
Deinococcus radiodurans(DR) is a model organism to study radiation resistance. PprA protein(pleiotropic protein promoting DNA repair) is a unique, pleiotropic protein promoting DNA repair in DR. This article reviewed its possible function in DNA damage repairing, maintenance of genome stability and other aspects. Furthermore, we analyze its domain of pprA genes and by bioinformatics and predict interaction protein with PprA protein, in order to predict its function and understand the mechanisms and pathways it plays.
Deinococcus radiodurans(DR) is a model organism to study radiation resistance. PprA protein(pleiotropic protein promoting DNA repair) is a unique, pleiotropic protein promoting DNA repair in DR. This article reviewed its possible function in DNA damage repairing, maintenance of genome stability and other aspects. Furthermore, we analyze its domain of pprA genes and by bioinformatics and predict interaction protein with PprA protein, in order to predict its function and understand the mechanisms and pathways it plays.
2015, 39(2): 154-156, 160.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.011
Abstract:
v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation represents the most common oncogenic event in papillary thyroid cancer(PTC). The value of BRAF mutation in the diagnosis and guiding treatment of PTC has achieved enthusiastic investigation since the initiation and progression of PTC has been correlated with BRAF mutation. However, existing evidence does not suggest BRAF mutation as an independent factor in guiding surgical approach, stratifying recurrence risk, or selecting postoperative radioiodine therapy for PTC patients. Although sorafenib and selumetinib have effectively improved the prognosis of patients with radioactive iodine-refractory PTC, such efficacy is independent of BRAF mutation status
v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation represents the most common oncogenic event in papillary thyroid cancer(PTC). The value of BRAF mutation in the diagnosis and guiding treatment of PTC has achieved enthusiastic investigation since the initiation and progression of PTC has been correlated with BRAF mutation. However, existing evidence does not suggest BRAF mutation as an independent factor in guiding surgical approach, stratifying recurrence risk, or selecting postoperative radioiodine therapy for PTC patients. Although sorafenib and selumetinib have effectively improved the prognosis of patients with radioactive iodine-refractory PTC, such efficacy is independent of BRAF mutation status
2015, 39(2): 157-160.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.012
Abstract:
Traumatic brain injury(TBI)is the damage of brain tissue caused by external injuries and it has a higher incidence of incidence rate and death rate. It is difficult to diagnose TBI with classic medical imaging technology. PET is an imaging technology that can measure the cerebral glycometabolism and cerebral blood flow quantitatively. It can display the brain functional change caused by TBI. Currently, 18F-FDG PET imaging can diagnose TBI by evaluating the cerebral glycometabolism and cerebral blood flow variation. This paper has comprehensively discussed the current conditions of 18F-FDG PET imaging and cerebral blood flow perfusion PET imaging.
Traumatic brain injury(TBI)is the damage of brain tissue caused by external injuries and it has a higher incidence of incidence rate and death rate. It is difficult to diagnose TBI with classic medical imaging technology. PET is an imaging technology that can measure the cerebral glycometabolism and cerebral blood flow quantitatively. It can display the brain functional change caused by TBI. Currently, 18F-FDG PET imaging can diagnose TBI by evaluating the cerebral glycometabolism and cerebral blood flow variation. This paper has comprehensively discussed the current conditions of 18F-FDG PET imaging and cerebral blood flow perfusion PET imaging.
2015, 39(2): 161-164.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.013
Abstract:
Cerebral glioma is the most common primary brain tumor with high rates of mortality and morbidity. Conventional imaging methods demonstrate some limitations in preoperative grading, prognostic evaluation, and differentiation between tumor recurrence and radiation necrosis for patients with cerebral gliomas. Positron emission tomography/computed tomography (PET/CT) is an ideal imaging tool for noninvasive examination of underlying tumor biology. Recently, various molecular imaging pathways and tracers for the diagnosis and therapeutic monitoring of gliomas have been studied. 11C-methionine (11C-MET)PET/CT provides various advantages in diagnosing primary gliomas. These benefits include accurate diagnosis, grading, prognosis, assessment of tumor extent, biopsy, radiotherapy planning, and differentiation between radiation necrosis and tumor recurrence. This article provides an overview of the current application of 11C-MET PET/CT in the diagnosis of cerebral gliomas.
Cerebral glioma is the most common primary brain tumor with high rates of mortality and morbidity. Conventional imaging methods demonstrate some limitations in preoperative grading, prognostic evaluation, and differentiation between tumor recurrence and radiation necrosis for patients with cerebral gliomas. Positron emission tomography/computed tomography (PET/CT) is an ideal imaging tool for noninvasive examination of underlying tumor biology. Recently, various molecular imaging pathways and tracers for the diagnosis and therapeutic monitoring of gliomas have been studied. 11C-methionine (11C-MET)PET/CT provides various advantages in diagnosing primary gliomas. These benefits include accurate diagnosis, grading, prognosis, assessment of tumor extent, biopsy, radiotherapy planning, and differentiation between radiation necrosis and tumor recurrence. This article provides an overview of the current application of 11C-MET PET/CT in the diagnosis of cerebral gliomas.
2015, 39(2): 165-169.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.014
Abstract:
Pulmonary aspiration is a common disease of respiratory system. The morbidity and mortality of the disease is high since it lacks typical clinical symptoms and generally can hardly be detected until severe lung damages caused. Consequently, early diagnosis of pulmonary aspiration is of vital importance. The pathogenetic mechanism of pulmonary aspiration is complicated and diverse. Since its clinical features are not atypical and specific diagnostic method is not available, there are lots of patients delayed in diagnosis and treatment. In the European and American countries, radionuclide imaging is the most commonly used clinical method for pulmonary aspiration diagnosis. However, there are few related researches and reports in China. The writer has summarized the progress of radionuclide imaging for pulmonary aspiration diagnosis.
Pulmonary aspiration is a common disease of respiratory system. The morbidity and mortality of the disease is high since it lacks typical clinical symptoms and generally can hardly be detected until severe lung damages caused. Consequently, early diagnosis of pulmonary aspiration is of vital importance. The pathogenetic mechanism of pulmonary aspiration is complicated and diverse. Since its clinical features are not atypical and specific diagnostic method is not available, there are lots of patients delayed in diagnosis and treatment. In the European and American countries, radionuclide imaging is the most commonly used clinical method for pulmonary aspiration diagnosis. However, there are few related researches and reports in China. The writer has summarized the progress of radionuclide imaging for pulmonary aspiration diagnosis.
2015, 39(2): 170-174, 187.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.015
Abstract:
Tumor Angiogenesis is one of the key requirements of tumor growth and metastasis. Tumour-induced angiogenesis is a multistep process that controlled by growth factors, cellular receptors and adhesion molecules, such as vascular endothelial growth factor, αvβ3 integrin, extracellular matrix proteins, prostate-specific membrane antige. They have become a common molecular target which has a potential value in angiogenesis molecular imaging and therapy at present. It is an important subject of modern medical imaging in developing a new imaging method which can accurate noninvasive assessment of tumor angiogenesis and tumor anti-angiogenesis therapy effect.
Tumor Angiogenesis is one of the key requirements of tumor growth and metastasis. Tumour-induced angiogenesis is a multistep process that controlled by growth factors, cellular receptors and adhesion molecules, such as vascular endothelial growth factor, αvβ3 integrin, extracellular matrix proteins, prostate-specific membrane antige. They have become a common molecular target which has a potential value in angiogenesis molecular imaging and therapy at present. It is an important subject of modern medical imaging in developing a new imaging method which can accurate noninvasive assessment of tumor angiogenesis and tumor anti-angiogenesis therapy effect.
2015, 39(2): 175-179.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.016
Abstract:
Hepatocellular carcinoma have high fatality rate and be diagnosed already in middle or late period with other common methods. PET/CT is a new kind of imaging examination technique, as a functional imaging of the molecular level. PET/CT has made certain progress in hepatocellular carcinoma(HCC) diagnosis, prognosis and therapeutic evaluation, which play an increasingly important role in recent years. Combined use of a variety of tracer can improve PET/CT imaging for HCC diagnosis sensitivity and specific degrees. This article aimed to explore the progress on the aspects above reviewed.
Hepatocellular carcinoma have high fatality rate and be diagnosed already in middle or late period with other common methods. PET/CT is a new kind of imaging examination technique, as a functional imaging of the molecular level. PET/CT has made certain progress in hepatocellular carcinoma(HCC) diagnosis, prognosis and therapeutic evaluation, which play an increasingly important role in recent years. Combined use of a variety of tracer can improve PET/CT imaging for HCC diagnosis sensitivity and specific degrees. This article aimed to explore the progress on the aspects above reviewed.
2015, 39(2): 180-183.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.017
Abstract:
As the cell therapy moves forward, adopting effective cell tracking techniques in living cells plays an important role in evaluating curative effects after cell therapy and monitoring differentiation and proliferation, migration and survival status of transplanted cells, which hold promise and potential to address many unmet clinical needs. So cell tracking technique in vivo is one of crucial techniques to transform cell therapy from basic research to clinical promoted application. This article is mainly to overview recent development and feasibility of cell tracking with optical and MR imaging.
As the cell therapy moves forward, adopting effective cell tracking techniques in living cells plays an important role in evaluating curative effects after cell therapy and monitoring differentiation and proliferation, migration and survival status of transplanted cells, which hold promise and potential to address many unmet clinical needs. So cell tracking technique in vivo is one of crucial techniques to transform cell therapy from basic research to clinical promoted application. This article is mainly to overview recent development and feasibility of cell tracking with optical and MR imaging.
2015, 39(2): 184-187.
doi: 10.3760/cma.j.issn.1673-4114.2015.02.018
Abstract:
Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with 99Tcm labeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.
Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with 99Tcm labeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.
2015, 39(2): 184-187.
doi: 10.3760/cma.i.issn.1673-4114.2015.02.018
Abstract:
Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with 99Tcmlabeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.
Synovial pannus formation is the most basic and important pathological manifestation for rheumatoid arthritis(RA). This manifestation can lead to the destruction of cartilage, bone, and joint, ultimately leading to joint deformity and loss of function. Angiogenesis plays an important role in the process of synovial pannus formation, as well as the erosion and destruction of the pannus. Angiogenesis enhances the invasiveness of the pannus and promotes destruction of bone and cartilage. Angiogenesis began early in and throughout the course of the disease. Thus, angiogenesis should be observed for early diagnosis of RA, judgment of active stage, and assessment of therapy and prognosis. To examine the change rule of RA angiogenesis, the development course and antagonists of angiogenesis should inhibit this process to determine a further theoretical basis and novel drugs for targeted therapy with 99Tcmlabeled arginine-glycine-aspartic acid(Arg-Gly-Asp, RGD) peptides. These peptides demonstrate high selectivity and affinity with the integrin αvβ3 receptor and can show angiogenesis-imaging agents via SPECT imaging in the body.
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