2005 Vol. 29, No. 4
Display Method:
2005, 29(4): 145-147,151.
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Abstract:
The 2005 52nd Society of Nucfear Madicine (SNM) Annual Meeting was held June 1822, 2005 in Toronto, Canada. We've discussed five issues as follows:① What can we depend on to boost the collaboration with clinic subjects and make nuclear medicine thrive and grow internationally? ② The rapid development of molecular imaging. ③ The importance of radiopharmaceutical design and development. ④ The new instruments propel nuclear medicine forward. ⑤ The economic value of nuclear medicine is now being recognized.
The 2005 52nd Society of Nucfear Madicine (SNM) Annual Meeting was held June 1822, 2005 in Toronto, Canada. We've discussed five issues as follows:① What can we depend on to boost the collaboration with clinic subjects and make nuclear medicine thrive and grow internationally? ② The rapid development of molecular imaging. ③ The importance of radiopharmaceutical design and development. ④ The new instruments propel nuclear medicine forward. ⑤ The economic value of nuclear medicine is now being recognized.
2005, 29(4): 148-151.
Abstract:
Functional neuroimaging studies are essential in the evaluation of individuals with partial epilepsy syndromes. Magnetic resonance spectroscopy(MRS) allows us to investigate cerebral metabolites and some Reduction in various metabolite concentrations has proven to be prognostieally valuable no structure abnormality is identified. PET using deoxyglueose demonstrates areas of reduced glucose metabolism, which are the hallmark of epileptogenie zones and usually extend beyond the underlying anatomical region. It is useful in temporal lobe epilepsy for lateralization, however, results extratemporal lobe epilepsy have been less favorable. More promising is the use of benzodiazepine receptor ligands, which are reduced in the epileptogenie zone in a more restricted distribution. This appears to be helpful in the localization of extratemporal seizure foci. Peri-ietal SPECT measures increases blood flow during the ietal event and is beneficial in patients with normal MRI studies to determine lateralization and localization of ietal onset zone.
Functional neuroimaging studies are essential in the evaluation of individuals with partial epilepsy syndromes. Magnetic resonance spectroscopy(MRS) allows us to investigate cerebral metabolites and some Reduction in various metabolite concentrations has proven to be prognostieally valuable no structure abnormality is identified. PET using deoxyglueose demonstrates areas of reduced glucose metabolism, which are the hallmark of epileptogenie zones and usually extend beyond the underlying anatomical region. It is useful in temporal lobe epilepsy for lateralization, however, results extratemporal lobe epilepsy have been less favorable. More promising is the use of benzodiazepine receptor ligands, which are reduced in the epileptogenie zone in a more restricted distribution. This appears to be helpful in the localization of extratemporal seizure foci. Peri-ietal SPECT measures increases blood flow during the ietal event and is beneficial in patients with normal MRI studies to determine lateralization and localization of ietal onset zone.
2005, 29(4): 152-154.
Abstract:
The assessment of myocardial viability is clinically significant for doctors in determining which patient to undergo coronary artery bypass graft (CABG), and pridicting the sugery effect and prognosis as well. 201T1 rest/redistribution imaging can effectively and economically assess the myocardial viability, The gated SPECT imaging can provide the motion information of the myocardium which enhance the sensitivity and specificity in evaluating the myocardial viability in some equivocal cases. 18F-FDG myocardial metabolic imaging combined with myocardial perfusion imaging still remain as the "Golden Standard" in assessing the myocardial viability. Besides, myocardial perfusion imaging can effectively distinguish the re-stenosis from new coronary arterial stenosis in post-CABG patients with angina symptoms.
The assessment of myocardial viability is clinically significant for doctors in determining which patient to undergo coronary artery bypass graft (CABG), and pridicting the sugery effect and prognosis as well. 201T1 rest/redistribution imaging can effectively and economically assess the myocardial viability, The gated SPECT imaging can provide the motion information of the myocardium which enhance the sensitivity and specificity in evaluating the myocardial viability in some equivocal cases. 18F-FDG myocardial metabolic imaging combined with myocardial perfusion imaging still remain as the "Golden Standard" in assessing the myocardial viability. Besides, myocardial perfusion imaging can effectively distinguish the re-stenosis from new coronary arterial stenosis in post-CABG patients with angina symptoms.
2005, 29(4): 155-158.
Abstract:
The techniques development of myocardial perfusion imaging quantitative analysis, gated SPECT imaging, 18F-fluorodeoxyglucose(18F-FDG) and 99Tcm-sestamibi(99Tcm-MIBI) dual isotope simultaneous acquisition (DISA), interventional echocar-diography and magnetic resonance imaging (MRI) have enhanced the recognition of myocardium viability. The combined applications of interventional echocardiography, myocardial perfusion imaging and myocardial metabolic imaging may improve accuracy for assessing viability. The assessment of myocardial viability allows identification of patients who are most likely to benefit from coronary revascularization, and prognosis of increase in left ventricular ejection fraction (LVEF) and improvement in heart failure symptoms postopera-tively.
The techniques development of myocardial perfusion imaging quantitative analysis, gated SPECT imaging, 18F-fluorodeoxyglucose(18F-FDG) and 99Tcm-sestamibi(99Tcm-MIBI) dual isotope simultaneous acquisition (DISA), interventional echocar-diography and magnetic resonance imaging (MRI) have enhanced the recognition of myocardium viability. The combined applications of interventional echocardiography, myocardial perfusion imaging and myocardial metabolic imaging may improve accuracy for assessing viability. The assessment of myocardial viability allows identification of patients who are most likely to benefit from coronary revascularization, and prognosis of increase in left ventricular ejection fraction (LVEF) and improvement in heart failure symptoms postopera-tively.
2005, 29(4): 159-161.
Abstract:
Brachytherapy is one of the most main management to prostate carcinoma. This method has been rapidly accepted in clinical application since it is a convenient, little-traumatic, and outpatient therapy. With the development of techniques of production of radio-seeds, imaging modality and three-dimensional radiotherapy plan system, bachytherapy has been made a virtually progress in improving curative-effect and reducing damage to surrounding normal tissue.
Brachytherapy is one of the most main management to prostate carcinoma. This method has been rapidly accepted in clinical application since it is a convenient, little-traumatic, and outpatient therapy. With the development of techniques of production of radio-seeds, imaging modality and three-dimensional radiotherapy plan system, bachytherapy has been made a virtually progress in improving curative-effect and reducing damage to surrounding normal tissue.
2005, 29(4): 161-163.
Abstract:
Objective: To investigate antipersonnel effectiveness of Hela cell and therapeutic effectiveness of tumor of 125I sealed seed source. Method: 125I sealed seed source was implanted in tumor of bearingtumor mice, therapeutic effectiveness of tumor and toxicity of blood were observed. Result: 125I sealed seed source had antipersonnel effectiveness for Hela cell, and the range of antipersonnel effectiveness was 1.6~2.4mm after 48h irradiation, and controlled patently the growth of tumor, toxicity of blood was not found. Conclusion: 125I sealed seed source could control effectively the growth of tumor and obtain therapeutic purpose.
Objective: To investigate antipersonnel effectiveness of Hela cell and therapeutic effectiveness of tumor of 125I sealed seed source. Method: 125I sealed seed source was implanted in tumor of bearingtumor mice, therapeutic effectiveness of tumor and toxicity of blood were observed. Result: 125I sealed seed source had antipersonnel effectiveness for Hela cell, and the range of antipersonnel effectiveness was 1.6~2.4mm after 48h irradiation, and controlled patently the growth of tumor, toxicity of blood was not found. Conclusion: 125I sealed seed source could control effectively the growth of tumor and obtain therapeutic purpose.
2005, 29(4): 164-166.
Abstract:
Leptin, a protein product encoded by the obese gene, has relationship with the regulation of the metabolism. This compound has been implicated for the regulation of energy balance, fat metabolism and has an important part in neural endocrinology and reproductive system and hematogenous system. Leptin has relations with many tumors diseases. It implies that leptin will be acted as a new tumor marker has an important role in early diagnoses of the tumors.
Leptin, a protein product encoded by the obese gene, has relationship with the regulation of the metabolism. This compound has been implicated for the regulation of energy balance, fat metabolism and has an important part in neural endocrinology and reproductive system and hematogenous system. Leptin has relations with many tumors diseases. It implies that leptin will be acted as a new tumor marker has an important role in early diagnoses of the tumors.
2005, 29(4): 166-168.
Abstract:
The radiation induced damage of kidney, brain and salivary glands is an important complicating disease after limit radiotherapy. The routine technology of nuclear medicine, such as tracing and imaging technique conduce to dose-effect calculations used in the planning of modern radiotherapy to three major organ systems and early detection of irradiation induced organ dysfunctions, as well as increased availability of radiotherapy.
The radiation induced damage of kidney, brain and salivary glands is an important complicating disease after limit radiotherapy. The routine technology of nuclear medicine, such as tracing and imaging technique conduce to dose-effect calculations used in the planning of modern radiotherapy to three major organ systems and early detection of irradiation induced organ dysfunctions, as well as increased availability of radiotherapy.
2005, 29(4): 169-170.
Abstract:
There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it's expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of 99Tcm-sestamibi (99Tcm-MIBI) is a sensitiveness index for low-level P-gp expression.
There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it's expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of 99Tcm-sestamibi (99Tcm-MIBI) is a sensitiveness index for low-level P-gp expression.
2005, 29(4): 171-176.
Abstract:
The application of radiation in the field of medicine is the most active area. Due to the rapid and strong development of intervention radiology at present near 20 years, particularly, the medical workers become a popularize group which most rapid increasing and also receiving the must high of professional exposure dose. Because, inter alias, radiation protection management nag training have not fully follow up, the aware of radioactive protection and appropriate approach have tot fully meet the development and need, the professional exposure dose received by medical workers, especially those being engaged in intervention radiology, are more higher, as well as have not yet fully receiving the complete personal dose monitoring, the medical workers become the population group which should be paid the most attention to. The writer would advice in this paper that all medical workers who being received a professional radiation exposure should pay more attention to the safety and healthy they by is strengthening radiation protection and receiving complete personal dose monitoring.
The application of radiation in the field of medicine is the most active area. Due to the rapid and strong development of intervention radiology at present near 20 years, particularly, the medical workers become a popularize group which most rapid increasing and also receiving the must high of professional exposure dose. Because, inter alias, radiation protection management nag training have not fully follow up, the aware of radioactive protection and appropriate approach have tot fully meet the development and need, the professional exposure dose received by medical workers, especially those being engaged in intervention radiology, are more higher, as well as have not yet fully receiving the complete personal dose monitoring, the medical workers become the population group which should be paid the most attention to. The writer would advice in this paper that all medical workers who being received a professional radiation exposure should pay more attention to the safety and healthy they by is strengthening radiation protection and receiving complete personal dose monitoring.
2005, 29(4): 176-179.
Abstract:
With the development of nuclear energy production, rare-earth element industry and use of radioactive sources, potential possibility of radiation contamination exits. Analysis of natural and artificial radioactivity in waters was calTied out in order to protect our environment and public health. Current progress in research of radioactivity in surface waters will be viewed in the article.
With the development of nuclear energy production, rare-earth element industry and use of radioactive sources, potential possibility of radiation contamination exits. Analysis of natural and artificial radioactivity in waters was calTied out in order to protect our environment and public health. Current progress in research of radioactivity in surface waters will be viewed in the article.
2005, 29(4): 179-185,封三.
Abstract:
Strategic National Stockpile Radiation Working Group developed a consensus document to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries for aiding individuals injured by a terrorist act involving radioactive material. Scenarios have been developed for such acts that include a range of exposures resulting in few to many casualties. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. Documentation of clinical signs and symptoms (affecting the hematopoietic, gastrointestinal, cerebrovascular, and cutaneous systems) over time is essential for triage of victims, selection of therapy, and assignment of prognosis.
Strategic National Stockpile Radiation Working Group developed a consensus document to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries for aiding individuals injured by a terrorist act involving radioactive material. Scenarios have been developed for such acts that include a range of exposures resulting in few to many casualties. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. Documentation of clinical signs and symptoms (affecting the hematopoietic, gastrointestinal, cerebrovascular, and cutaneous systems) over time is essential for triage of victims, selection of therapy, and assignment of prognosis.
2005, 29(4): 186-189.
Abstract:
The dose rate with which radiation is delivered significantly affects the biological response to radiation and reducing the dose rate decreases the biological effect. However, DNA damage introduced at a reduced rate does not activate the DNA damage sensor ATM and that failure to activate ATM-associated repair pathways contributes to the increased lethality of continuous radiation exposures, which has been termed the "inverse dose rate effect". Under continuous low dose rate irradiation, there are two major pathways by which DSB's can be repaired, nonhomologous end joining (NHEJ), and homologous recombination(HR), which play an important role in sublethal damage repair and the generation of dose-rate effect. A change in sensitivity is modified if DNA damage can be repaired with high fidelity. The cells will lead to apoptosis if the cell DNA damage is not sufficiently repaired. The p53 gene is a key factor in the radiation-induced the cell cycle arrest and the activation of apoptosis after exposure to low dose-rate irradiation.
The dose rate with which radiation is delivered significantly affects the biological response to radiation and reducing the dose rate decreases the biological effect. However, DNA damage introduced at a reduced rate does not activate the DNA damage sensor ATM and that failure to activate ATM-associated repair pathways contributes to the increased lethality of continuous radiation exposures, which has been termed the "inverse dose rate effect". Under continuous low dose rate irradiation, there are two major pathways by which DSB's can be repaired, nonhomologous end joining (NHEJ), and homologous recombination(HR), which play an important role in sublethal damage repair and the generation of dose-rate effect. A change in sensitivity is modified if DNA damage can be repaired with high fidelity. The cells will lead to apoptosis if the cell DNA damage is not sufficiently repaired. The p53 gene is a key factor in the radiation-induced the cell cycle arrest and the activation of apoptosis after exposure to low dose-rate irradiation.
2005, 29(4): 190-192,封三.
Abstract:
The clinic work of low-dose irradiation in the prostate cancer has already accumulated a large amont of experience. Studied on the biological effect of continuous low-dose rate was shown in the following several aspects:① the inverse dose rate effect; ② radio sensitivity; ③ apoptosis and relevant protein expression of apoptosis; ④ cell cycle and relevant protein expression of cell cycle; ⑤ repair gene cancer.
The clinic work of low-dose irradiation in the prostate cancer has already accumulated a large amont of experience. Studied on the biological effect of continuous low-dose rate was shown in the following several aspects:① the inverse dose rate effect; ② radio sensitivity; ③ apoptosis and relevant protein expression of apoptosis; ④ cell cycle and relevant protein expression of cell cycle; ⑤ repair gene cancer.
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