Research of ⁹⁹Tc^m-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor

There has a overexpression ofmultidrug resistance (MDR) gene in most tumor. It is very important that it's expression product P-glycoprotein(P-gp)in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of ⁹⁹Tc^m-sestamibi (⁹⁹Tc^m-MIBI) is a sensitiveness index for low-level P-gp expression.