2004 Vol. 28, No. 6
Display Method:
2004, 28(6): 241-245.
[PDF 403KB]
Abstract:
Positron emission tomography (PET) is a nuclear medical imaging technique that permits the use of positron-labeled molecular imaging probes for non-invasive assays of biochemical processes. As the leading technology in nuclear medicine, PET has extended its applications from the clinical field to the study of small laboratory animals. In recent years, the development of new detector technology has dramatically improved the spatial resolution and image quality of small animal PET scanner, which is being used increasingly as a basic tool in modern biomedical research. In particular, small animal PET will play an important role in drug discovery and development, in the study of small animal models of human diseases, in characterizing gene expression and in many other ways.
Positron emission tomography (PET) is a nuclear medical imaging technique that permits the use of positron-labeled molecular imaging probes for non-invasive assays of biochemical processes. As the leading technology in nuclear medicine, PET has extended its applications from the clinical field to the study of small laboratory animals. In recent years, the development of new detector technology has dramatically improved the spatial resolution and image quality of small animal PET scanner, which is being used increasingly as a basic tool in modern biomedical research. In particular, small animal PET will play an important role in drug discovery and development, in the study of small animal models of human diseases, in characterizing gene expression and in many other ways.
2004, 28(6): 246-249.
Abstract:
The ischemic penumbra is the target of therapy for ischemic stroke patients, so it is extremely important to investigate an imaging technique that may identify accurately the viability of cerebral tissues early. The neuroreceptor imaging with positron emission tomography has achieved some successes in this study field, in particular, the 11C-flumazenil receptor imaging, which can not only differentiate between the neurons of functional impairment and those of morphological destruction, and then distinguish the is-chemic penumbra from the irreversible damage tissues, but predict the malignant course of cerebral infarction. Consequently, these will help to select the patients benefiting from the intervention therapy and plan effectively the therapeutic strategies.
The ischemic penumbra is the target of therapy for ischemic stroke patients, so it is extremely important to investigate an imaging technique that may identify accurately the viability of cerebral tissues early. The neuroreceptor imaging with positron emission tomography has achieved some successes in this study field, in particular, the 11C-flumazenil receptor imaging, which can not only differentiate between the neurons of functional impairment and those of morphological destruction, and then distinguish the is-chemic penumbra from the irreversible damage tissues, but predict the malignant course of cerebral infarction. Consequently, these will help to select the patients benefiting from the intervention therapy and plan effectively the therapeutic strategies.
2004, 28(6): 249-252.
Abstract:
As the thyroidal membrane protein that mediates iodide transport into thyroid follicular cells, NIS plays a key role in thyroid pathophysiology and allows very effective use of radioiodine for therapy of thyroid cancer. Most studies have demonstrated decreased NIS expression levels in thyroid carcinomas. Retinoic acide and demethylation as well as histone deacetylase inhibitors treatment, have been explored with the aim of stimulating NIS expression and optimizing therapeutic responsiveness to 131I in thyroid cancer. In addition, cloning and molecular analysis of the NIS gene offer the possibility of a novel cytoreductive gene therapy strategy based on targeted NIS gene transfer into thyroidal tumors.
As the thyroidal membrane protein that mediates iodide transport into thyroid follicular cells, NIS plays a key role in thyroid pathophysiology and allows very effective use of radioiodine for therapy of thyroid cancer. Most studies have demonstrated decreased NIS expression levels in thyroid carcinomas. Retinoic acide and demethylation as well as histone deacetylase inhibitors treatment, have been explored with the aim of stimulating NIS expression and optimizing therapeutic responsiveness to 131I in thyroid cancer. In addition, cloning and molecular analysis of the NIS gene offer the possibility of a novel cytoreductive gene therapy strategy based on targeted NIS gene transfer into thyroidal tumors.
2004, 28(6): 253-256.
Abstract:
PET imaging has important value in the study of neural stem cell transplantation treating Parkinson's disease, especial in the evaluation of the effect, the study of treating mechanisms and the comparation of effect in different transplantation places. PET imaging as a non-invasive method plays a more and more important role in the study of neural stem cell transplantation treating Parkinson's disease.
PET imaging has important value in the study of neural stem cell transplantation treating Parkinson's disease, especial in the evaluation of the effect, the study of treating mechanisms and the comparation of effect in different transplantation places. PET imaging as a non-invasive method plays a more and more important role in the study of neural stem cell transplantation treating Parkinson's disease.
2004, 28(6): 256-259.
Abstract:
With the changing of life style and dietary structure, the incidence of atherosclerosis, whose pathogenesis are not completely understood, tends to increase. Finding out positive pathogenesis and making effective precaution and therapy are present emphasis. The antiinflammation and profibrosis of TGF-β in the progress of atherosclerosis are reviewed in the article.
With the changing of life style and dietary structure, the incidence of atherosclerosis, whose pathogenesis are not completely understood, tends to increase. Finding out positive pathogenesis and making effective precaution and therapy are present emphasis. The antiinflammation and profibrosis of TGF-β in the progress of atherosclerosis are reviewed in the article.
2004, 28(6): 259-262.
Abstract:
Osteoporosis has many causes and different clinical presentations, all characterized by a loss of bone tissue to a level below that required for mechanical support of every day activities, resulting in nontraumatic fractures. Bone turnover may range from accelerated to severely reduced. Quantification of skeletal uptake of radionuclide have been evaluated to assess bone turnover. Different technical approaches have been described over years. Radionuclide quantitative bone scaning may be reasonably accurate and useful for the assessment of osteoporosis.
Osteoporosis has many causes and different clinical presentations, all characterized by a loss of bone tissue to a level below that required for mechanical support of every day activities, resulting in nontraumatic fractures. Bone turnover may range from accelerated to severely reduced. Quantification of skeletal uptake of radionuclide have been evaluated to assess bone turnover. Different technical approaches have been described over years. Radionuclide quantitative bone scaning may be reasonably accurate and useful for the assessment of osteoporosis.
2004, 28(6): 262-264.
Abstract:
The article discuss the advances in 99Tcm-sestamibi scintimammography to diagnose P-gly-coprotein of breast cancer in multidrug resistance. As a kind of noninvasive fuctional test imaging technology, SPECT can be used to diagnose P-glycoprotein expression in breast cancer and can make decision for clinical treatment.
The article discuss the advances in 99Tcm-sestamibi scintimammography to diagnose P-gly-coprotein of breast cancer in multidrug resistance. As a kind of noninvasive fuctional test imaging technology, SPECT can be used to diagnose P-glycoprotein expression in breast cancer and can make decision for clinical treatment.
2004, 28(6): 265-266.
Abstract:
The secondary hypothyroidism is the most important intercurrent disease after radioiodine therapy. The early hypothyroidism and the late hypothyroidism are incompletely different in pathogenesis. It needs researching further. There has not yet been an affirmable answer to choose the distillates from animal hypothyroid extract or complex preparation of levo-thyroxine in replacement treatment.
The secondary hypothyroidism is the most important intercurrent disease after radioiodine therapy. The early hypothyroidism and the late hypothyroidism are incompletely different in pathogenesis. It needs researching further. There has not yet been an affirmable answer to choose the distillates from animal hypothyroid extract or complex preparation of levo-thyroxine in replacement treatment.
2004, 28(6): 267-270.
Abstract:
Alpha-particles can lead to cell death, proliferation and cancerization, but genetic damage is more worth concerning. Many studies have shown that alpha-particles also cause a procedure of genomic instability and the damage can transfer to filial generations. The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.
Alpha-particles can lead to cell death, proliferation and cancerization, but genetic damage is more worth concerning. Many studies have shown that alpha-particles also cause a procedure of genomic instability and the damage can transfer to filial generations. The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.
2004, 28(6): 270-274.
Abstract:
Cell adhesion molecules(CAMs) are a group of membrane or transmembrane glycoproteins which modulate the cell-cell and cell-extracellular matrix interaction. The role of CAMs is involved in cell adhesion, migration, differentiation and signal transduction. Ionizing radiation can induce the changes of the CAMs in normal tissue or tumor tissue, depending on irradiation dose and postirradiation time. A good dose-effect pattern was found between expression of CAMs and exposure dose. It means that change of CAMs induced by radiation has a potential of biodosimetry of radiation.
Cell adhesion molecules(CAMs) are a group of membrane or transmembrane glycoproteins which modulate the cell-cell and cell-extracellular matrix interaction. The role of CAMs is involved in cell adhesion, migration, differentiation and signal transduction. Ionizing radiation can induce the changes of the CAMs in normal tissue or tumor tissue, depending on irradiation dose and postirradiation time. A good dose-effect pattern was found between expression of CAMs and exposure dose. It means that change of CAMs induced by radiation has a potential of biodosimetry of radiation.
2004, 28(6): 274-277.
Abstract:
Ion irradiation exists broadly in the people's life. It can induce a series of the biological effect in body depending on the different type and dose of ionization. This article expound the effect of ion irradiation on the biological function of immune system, affording the theorial guide in the appreciation, precaution and treatment of irradiation injury.
Ion irradiation exists broadly in the people's life. It can induce a series of the biological effect in body depending on the different type and dose of ionization. This article expound the effect of ion irradiation on the biological function of immune system, affording the theorial guide in the appreciation, precaution and treatment of irradiation injury.
2004, 28(6): 278-280.
Abstract:
p21 gene is a negative regulator of cell cycle, which affect cell cycle progression arrest at G1 and G2 by some factors induced. p21 gene plays an important role to maintain genomic stability. Radiation and TGFβ1, TNFα, PTEN, IGF can increase p21 gene expression, however E1A, c-jun, Tbx2, PLD1 and PLD2 can inhibit p21 gene expression.
p21 gene is a negative regulator of cell cycle, which affect cell cycle progression arrest at G1 and G2 by some factors induced. p21 gene plays an important role to maintain genomic stability. Radiation and TGFβ1, TNFα, PTEN, IGF can increase p21 gene expression, however E1A, c-jun, Tbx2, PLD1 and PLD2 can inhibit p21 gene expression.
2004, 28(6): 281-283.
Abstract:
Subtract In studying the cell death mechanism by radioactivity, people discovered that apoptosis is a kind of form in the died cell induced by radioactivity. Meanwhile, apoptosis is closely related with radioactivity. In the recently years, there are more and more article about apoptosis induced by radioactivity. The article review the phenomenon about apoptosis induced by radioactivity and the newest research about improving tumor control by radioactivity inducing apoptosis.
Subtract In studying the cell death mechanism by radioactivity, people discovered that apoptosis is a kind of form in the died cell induced by radioactivity. Meanwhile, apoptosis is closely related with radioactivity. In the recently years, there are more and more article about apoptosis induced by radioactivity. The article review the phenomenon about apoptosis induced by radioactivity and the newest research about improving tumor control by radioactivity inducing apoptosis.
Submit
Author Login
Referees
Editor-in-Chief
Editor Center
Email alert
RSS
