The regulation of radiation and cytokines to p21 gene expression

YAN Feng-qin, JU Gui-zhi. The regulation of radiation and cytokines to p21 gene expression[J]. Int J Radiat Med Nucl Med, 2004, 28(6): 278-280.

Citation:

YAN Feng-qin, JU Gui-zhi. The regulation of radiation and cytokines to p21 gene expression[J]. Int J Radiat Med Nucl Med, 2004, 28(6): 278-280.

Citation:

YAN Feng-qin, JU Gui-zhi. The regulation of radiation and cytokines to p21 gene expression[J]. Int J Radiat Med Nucl Med, 2004, 28(6): 278-280.

Abstract

p21 gene is a negative regulator of cell cycle, which affect cell cycle progression arrest at G₁ and G₂ by some factors induced. p21 gene plays an important role to maintain genomic stability. Radiation and TGFβ1, TNFα, PTEN, IGF can increase p21 gene expression, however E1A, c-jun, Tbx2, PLD1 and PLD2 can inhibit p21 gene expression.

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