PET molecular probes for early detection of Alzheimer's disease

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. The characteristic pathological lesions are deposits of β-amyloid plaques and neurofibrillary tangles after postmortem examination, and degeneration of cholinergic neurons of the basal forebrain. The positron emission tomography (PET) molecular probes targeting at β-amyloid plaques or acetylchergic is one of the most reliable tools for AD early detection.