FENG Yan-lin, TAN Jia-ju, LIANG Sheng, SUN Jing, WU Xiao-lian, Si Jian-hua, XIA Jiao-yun, WEN Guang-hua. Labeling of immuno-magnetic nanoparticle with[188Re(CO)3(H2O)3]+[J]. Int J Radiat Med Nucl Med, 2007, 31(4): 211-214.
Citation: FENG Yan-lin, TAN Jia-ju, LIANG Sheng, SUN Jing, WU Xiao-lian, Si Jian-hua, XIA Jiao-yun, WEN Guang-hua. Labeling of immuno-magnetic nanoparticle with[188Re(CO)3(H2O)3]+[J]. Int J Radiat Med Nucl Med, 2007, 31(4): 211-214.
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Labeling of immuno-magnetic nanoparticle with188Re(CO)3(H2O)3+

    Abstract
  • Objective To investigate a fine experiment condition of indirect labeling method that Hepama-1-SPIONs(supeiparamagnetic iron oxide nanoparticles)was labelled with rhenium-188 complex(188Re(CO)3(H2O)3+). Methods The Hepama-1-SPIONs bridged by bifunctional chelating agent 2-picolylamine-N,N-diacetic acid(PADA) was labelled rhenium-188-tricarbonyl complex prepared with high labeling yields. Results The labeling rate of 188Re(CO)3(H2O)3+-PADA-Hepama-1-SPIONs was more than 80%, and was extremely stable in vitro, The labeling rate of 188Re-(CO)3(H2O)3-PADA-Hepama-1-SPIONs was more than 90% after 48 in calf serum and isotonic Na chloride. Conclusions 188Re-(CO)3(H2O)3-PADA-Hepama-1-SPIONs shows it's fine stability and biological properties, and it is well worth further researching as bio-magnetically targeted radiotherapy for cancer.
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