Platelet derived growth factor and its receptor and the radiation resistance of tumor cells

Platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) are abnormally synthesized following the autocrine growth activation in a number of malignant tumors.PDGF is a effective mitogen and chemical agent,PDGFR belongs to tyrosine kinase receptors.After binding with corresponding ligand,PDGFR is activated and lead to activate a series of downstream signal pathways and has resulted in many biological effects.PDGF and PDGFR signal pathway is associated with radiation resistance of tumor cells,and the mechanism is likely to be related to cell proliferation,suppressing apoptosis,and regulating cell cycle arrest.