The research progress and medicine application of the ScFv antibody

Since the scholar of England and Japan had found the diphtheria antitoxin, the research of the antibody has experienced three phases:polyclonal antibodies, monoclonal antibodies and genetically engineered antibodies. In recent years, far more attention has been paid to single-chain antibody by researchers owing to it's small molecular, strong ability of penetration, short half-lives in blood, high specificity to combine with the corresponding antibody, weak immunogenicity and possibility to be expressed in prokaryocyte.