Comparison study of ¹⁸F-fluorodeoxyglucose PET-CT and 99Tc-methylene phospho-nate bone scan in detecting bone metastases

Objective To investigate the diagnostic value of ¹⁸F-fluorodcoxyglucose PET-CT and ^99mTc-methylene phosphonate whole body imaging in detection bone metastases.Methods ¹⁸F-FDG PET-CT and ^99mTc-MDP whole body bone scan were both performed in 93 patients with malignant tumors testified by pathology.Bone metastases were confirmed by pathology,X ray or CT or MRI and follow-up for not less than 2 years.Results Of the 93 patients 44 were confirmed to have bone metastases by 2 years follow-up or pathology.The sensitivity,specificity and accuracy of ¹⁸F-FDG PET-CT were 95.4%,91.8%,93.5%,and ^99mTc-MDP bone imaging were 90.9%,63.3%,76.3%,respectively.¹⁸F-FDG PET-CT has a better specificity (t=2.53,P<0.05)and accuracy (t=2.47,P<0.05)in detecting bone metastases than that of ^99mTc-MDP bone imaging.Conclusion PET-CT is a more valuable method in the diagnosis of bone metastases.