COX-2 inhibitors and enhancement of tumor radiosensitivity

Cyclooxygenase-2(COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies. COX-2 inhibitors are enhancers of tumor cells response to irradiation. The possible mechanisms consist of effect on cell cycle distribution, inhibition of repair from sublethal radiation damage, increasing susceptibility of cells to radiation-induced apoptosis.