The application of ⁹⁹Tc^m-MIBI imaging to detect multidrug resistance

Multidrug resistance is the main cause of chemotherapy failure,To detect multidrug resistance is helpful to develop chemotherapy regimens and more effective treatment of patients with tumors. ⁹⁹Tc^m-sestamibi is a transport sub-strate of mdr1-encoded P-glycoprotein and MRP.The lower ⁹⁹Tc^m-sestamibi accumulation indicates the higher expression of P-glycoprotein in tumor cells.It is also related to the expression of MRP.As a result,response to chemotherapy can be estimated before starting treatment by means of ⁹⁹Tc^m-sestamibi imaging and more effective protocol can be chosen.