Peptide as carrier for diagnosis and treatment

Due to their small size,peptide molecules exhibit farourablepharmacokinetic characterstics,such as rapid uptake by target tissue and rapid blook clearance,which potentiallyallowes images to be acquired earlier following the administration of a radiolabeled peptide radiopharmaceutical.The challenge is to label bioactive peptide with radioisotop with high specific activity without impairing the biological properties of the peptides.Molecular engineering technique now permits synthesis of a wide range of biologically active peptides that carry chelating groups in their structure without their receptor binding properties,thus permitting a high specific activity product.This article briefly summarized current experiments and clinicalapplication of the radiopharmaceuticals based on small receptor-binding peptides.The basic characteristics and the application of diagnosis and therapy with thrombus,infection/inflammation,and tumors are mainly reviewed.