Serum soluble intercellular adhesion molecule-l and its clinic significance in patients with liver cirrhosis

Objective: To investigate the level of serum soluble intercellular adhesion molecule-l(sICAM-1) and assess its role in liver function injury of cirrhosis. Methods: The sICAM-1 was measured by enzyme linked immunosorbent assay in serum samples collected from 50 liver cirrhosis patients and 20 healthy controls. Liver function tests performed in all samples. Results: Serum levels of sICAM-1 were signifi-cantly increased in patients with liver cirrhosis compared with healthy controls(t=2.874, P<0.01). Serum levels of sICAM-1 correlated positively with glutamic oxaloacetic transaminase(GOT)(r=0.2754, P<0.05) and negative with albumin(ALB) (r=-0.4812, P<0.01). Serum levels of sICAM-1 were correlated positively(r=0.3698, P<0.05) with assessment score of disease severity(Child classification). The contents of GOT, blood urea nitrogen(BUN), superfamily bilirubin(SB), creatinine(Cr), sICAM-1 were obviously lower than that of pretreatment. The contents of BUN、Cr、sICAM-1 comparision between recombination human growth hormone(rhGH) group and routine group in the after treatment were front obviously lower than that latter. The apparent efficiency, efficiency and inefficiency were 45.45%, 36.36% and 18.18% in rhGH group. The apparent efficiency, efficiency and inefficiency were 36.36%, 45.45%, and 27.27% in routine group. Conclusion: sICAM-1 is markedly elevated in liver cirrhosis and correlated with parameters of liver func-tion. sICAM-l may be useful in assessing the immunopathology of the disease process in liver cirrhosis.