The diagnostic value of ^99mTc-MIBI combined with ^99mTc-HL91 hypoxia imaging in primary lung cancer

Objective To assess the diagnostic value of ^99mTc-sestamibi (^99mTc-MIBI)combined with ^99mTc-labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (^99mTc-HL91) hypoxia imaging in primary lung cancer. Methods 60 patients with suspicious lung tumours underwent ^99mTc-MIBI and ^99mTc-HL91 imaging before operation. The diagnosis were confirmed with pathological study after surgeries. The diagnostic effectiveness of ^99mTc-MIBI and ^99mTc-HL91 in primary lung cancer were analyzed. Results 48 patients were found primary lung cancer with pathological study, other 12 patients were benign. The sensitivity, speccifity and accuracy obtained with ^99mTc-MIBI, ^99mTc-HL91 imaging and the combination of two methods were 89.6%(43/48), 77.1%(37/48), 95.8%(46/48); 75.0%(9/12), 91.7%(56/60), 83.3%(10/12) and 86.7%(52/60), 80.0%(48/60), 93.3%(56/60), respectively. Conclusion The combination of ^99mTc-MIBI and ^99mTc-HL91 hypoxia imaging may increase the the diagnostic effectiveness in primary lung cancer.