Effect of stereotactic radiotherapy on expression of CEA, CA125, CA153, and TSGF in patients with advanced lung adenocarcinoma

Objective To investigate the effects of stereotactic radiotherapy on the expression of serum carcinoembryonic antigen (CEA), glycoprotein antigen-125 (CA125), glycoprotein antigen-125 (CA153), and tumor specific growth factor (TSGF) in patients with advanced lung adenocarcinoma.

Methods Ninety-two patients with advanced lung adenocarcinoma admitted to Yantai Yantai m ountain hospital from January 2015 to May 2017 were equally and randomly divided into a control 46 cases: 28 males and 18 females with the average of (57.6±7.4) and an observation group 46 cases: 30 males and 16 females with the average of (58.2±8.1). The control group was treated with paclitaxel and cisplatin chemotherapy. Stereotactic radiotherapy was given on the basis of the group. The therapeutic effects; serum CEA, CA125, CA153, and TSGF expression levels; complications; and prognosis of the two groups were compared. χ² test and t test were used for the comparison among groups, and Kaplan Meier survival curve was used to analyze the survival rate.

Results The effective rates were 37.0% (17/46) and 17.4% (8/46) in the observation and the control group, respectively. The difference was significant (χ²=4.449, P=0.035). The expression levels of serum CEA, CA125, CA153, and TSGF in the observation group were significantly lower than those in the control group (t=6.987–13.575, all P=0.000). No significant difference was observed in terms of complications (χ²=0.562, P=0.337). The median survival times were 13.6 and 10.2 months in the observation and the control group, respectively. The difference was significant (U=126.0, P<0.01).

Conclusion Stereotactic radiography can promote lung adenocarcinoma therapy, reduce the level of serum tumor markers, and prolong the survival period of patients. Therefore, stereotactic radiography is worthy of clinical application.