The clinical value of different GFR methods in renal function evaluation of polycystic kidney diseases

ObjectivesTo investigate the application value of ⁹⁹Tc^m-diethylene-triaminepentaacetic acid(⁹⁹Tc^m-DTPA) renal dynamic imaging (method A) and blood creatinine estimation method(method B) in glomerular filtration rate (GFR) detection in different stages of polycystic kidney diseases.

MethodsA total of 59 polycystic kidney patients without dialysis were divided into the following groups by the gold standard method of double plasma (method C):Group A, GFR ≥ 60 mL/(min·1.73 m²) (including chronic kidney disease(CKD)1-2, 19 cases); Group B, 60 mL/(min·1.73 m²) > GFR ≥ 30 mL/(min·1.73 m²) (including CKD 3, 23 cases); Group C, GFR < 30 mL/(min·1.73 m²) (including CKD 4-5, 17 cases). The method A GFR and method B GFR were respectively matched with the method C GFR for t-test and Pearson correlation analysis.

Results(1) The method B GFR in Group A, B and C were (85.43±19.77), (46.56±15.48), (20.96±11.3) mL/(min·1.73 m²). The method C GFR were (80.58±16.2), (42.66±7.63), (18.61±7.21) mL/(min·1.73 m²) respectively. There was no significant difference between method B and method C in Groups A, B and C(t=-1.462, -1.592, -1.791, all P>0.05). In each group, the method B had a good correlation with method C (r=0.69, 0.68, 0.92, all P < 0.05); (2) The method A GFR in Group A, B and C were (75.39±20.75), (42.86±18.95), (25.85±14.91) mL/(min·1.73 m²). There was no significant difference between method A and method C in Groups A and B(t=1.255, -0.061, both P>0.05); A significant correlation between method A and method C in both groups was observed (r=0.55, 0.62, both P < 0.05); In Group C, no significant difference (t=-2.132, P < 0.05) and correlation (r=0.36, P>0.05) between method A and method C.

ConclusionsGate's method can evaluate renal function in the early stage of polycystic renal disease(CKD 1-3), but the late stage(CKD 4-5) is unsuitable. The blood creatinine estimation method (using the Cockcroft-Gault equation) can evaluate all stages of the renal function of the polycystic kidney disease.