Teng Ma, Ang Xuan, Jie Zhang, Chang Fu, Mengmeng Sun, Yang You, Junling Xu. Changes in resting-state brain glucose metabolism in patients with type 2 diabetes[J]. Int J Radiat Med Nucl Med, 2018, 42(1): 25-29. DOI: 10.3760/cma.j.issn.1673-4114.2018.01.005
Citation: Teng Ma, Ang Xuan, Jie Zhang, Chang Fu, Mengmeng Sun, Yang You, Junling Xu. Changes in resting-state brain glucose metabolism in patients with type 2 diabetes[J]. Int J Radiat Med Nucl Med, 2018, 42(1): 25-29. DOI: 10.3760/cma.j.issn.1673-4114.2018.01.005
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Changes in resting-state brain glucose metabolism in patients with type 2 diabetes

    Abstract
  • ObjectiveTo invetigate the metabolic changes in the resting brain glucose of patients with type 2 diabetes but without brain metastasis.
    MethodsA total of 96 patients with type 2 diabetes were confirmed by 18F-FDG PET/CT examination. The whole-body 18F-FDG PET/CT images of the patients were retrospectively analyzed. Ninety-six healthy subjects were included as controls for comparison. The metabolic changes in resting brain glucose of the 96 patients with type 2 diabetes were analyzed using a statistical parametric mapping software. Data were processed with two independent sample t test of voxel to voxel in the images.
    ResultsCompared with the control group, the hypometabolic brain areas in patients with type 2 diabetes were in the bilateral middle-inferior frontal, bilateral superior-heschl gyrus, bilateral superior-middle-lingual gyrus, calcarine cortex, bilateral inferior parietal gyrus, and bilateral wedge anterior lobe(t=5.51-6.42, all P < 0.001). Hypermetabolic areas were not observed in patients.
    ConclusionsThe reduced metabolic cerebral regions in the patients with type 2 diabetes involved a number of functional regions related to visual cortex and mood disorders.
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