Analysis of the serum homocysteine levels and the relevant risk factors of stroke on 834 high-risk community residents in Tianjin

Objective To identify the risk factors, level of exposure, and the population distribution in high-risk stroke people groups with age over 40 years in Hebei and Dongli Districts of Tianjin.To explore the level of serum homocystenine(Hcy) and its influencing factors.

Methods A total of 834 high-risk cases were accepted and divided into groups A(40~49), B(50~59), C(60~69), and D(≥70) based on age.Data were analyzed using ANOVA, Chi-square test, and binary logistic regression.

Results The serum Hcy values were(12.25±4.54), (14.01±6.67), (15.76±8.88), and(18.21±8.99)μmol/L for groups A to D, respectively.The level of serum Hcy increased with increasing age(F=15.476, P < 0.05).The rate of males with hyperhomocysteinemia(HHcy) was significantly higher than that of females(χ²=31.034, P < 0.05).The rates in the exposed group with previous stroke history and smoking were significantly higher than those of the non-exposed group(χ²=9.888 and 18.486, both P < 0.05).The rates in exposed group with transient ischemic attack(TIA), heart disease, high blood pressure, dyslipidemia, and lack of physical exercise showed no significant difference with the non-exposed group(χ²=0.688, 0.773, 2.042, 1.427 and 0.560, all P>0.05), but the rate in exposed group with diabetes was significantly lower than nonexposed group(χ²=30.345, P < 0.05).The independent risk factors of HHcy were male(OR=2.332), smoking(OR=1.537), and previous stroke history(OR=1.946) according to the logistic regression.

Conclusions The detection of serum Hcy is extremely important in screening high-risk populations for stroke.HHcy is an independent risk factor of stroke.It's important to take measures to reduce the incidence of stroke.