Shen Guo, Hongfeng Dai, Shuo Zhou, Wenxin Chen. Determination of residual organic solvents in 18F-FAC by gas chromatography[J]. Int J Radiat Med Nucl Med, 2015, 39(6): 458-461. DOI: 10.3760/cma.j.issn.1673-4114.2015.06.005
Citation: Shen Guo, Hongfeng Dai, Shuo Zhou, Wenxin Chen. Determination of residual organic solvents in 18F-FAC by gas chromatography[J]. Int J Radiat Med Nucl Med, 2015, 39(6): 458-461. DOI: 10.3760/cma.j.issn.1673-4114.2015.06.005
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Determination of residual organic solvents in 18F-FAC by gas chromatography

    Abstract
  • Objective To develop a method for residual organic solvent determination in 18F-fluoroacetate(18F-FAC) using capillary gas chromatography.
    Methods The residual organic solvents were separated on the HP-INNOWAX capillary chromatographic column using temperature programming. Nitrogen gas was used as the carrier gas, along with a flame ionization detector(FID). The FID and injector temperatures were 270℃ and 200℃, respectively, and the injection volume was 1 μl.
    Results Good linear relationships in the experimental concentrations(r=0.9999, 0.9973, 0.9988) were observed. The three residual organic solvents were separated completely; the average recoveries were 99.8%, 101.0%, and 97.5%, and the relative standard deviation values were 4.6%, 4.0%, and 1.5%, respectively.
    Conclusion The proposed method is simple, rapid, accurate, and highly sensitive, which can be used in detecting residual organic solvents in 18F-FAC.
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