Lu Lu, Junling Zhang, Deguan Li, Yueying Wang, Aimin Meng. Effects of 6 Gy 137Cs γ-irradiattion on the hematopoietic system of mice[J]. Int J Radiat Med Nucl Med, 2015, 39(5): 393-396. DOI: 10.3760/cma.j.issn.1673-4114.2015.05.009
Citation: Lu Lu, Junling Zhang, Deguan Li, Yueying Wang, Aimin Meng. Effects of 6 Gy 137Cs γ-irradiattion on the hematopoietic system of mice[J]. Int J Radiat Med Nucl Med, 2015, 39(5): 393-396. DOI: 10.3760/cma.j.issn.1673-4114.2015.05.009

Effects of 6 Gy 137Cs γ-irradiattion on the hematopoietic system of mice

  • Objective To observe the effects of 6 Gy 137Cs γ-irradiation on the hematopoietic system of mice.
    Methods Seventy male C57BL/6 mice were randomly divided into control and irradiated groups(n=35 each). The irradiation group mice received 6 Gy 137Cs γ-irradiation. Bodyweight, peripheral blood cell counts, bone marrow mononuclear cell counts, and reticulocyte percentage were measured at 1, 3, 7, 10, 14, 35, and 56 d after total body irradiation. CFU-GM was detected at 14, 35, and 56 d after 6 Gy 137Cs γ-irradiation.
    Results After irradiation, the bodyweight of irradiated mice decreased but slowly increased after 14 d. The peripheral blood of irradiated mice had significant changes in WBC and platelet counts: it respectively decreased to the lowest value at 7 and 10 d post-irradiation and subsequently increased slowly. The reticulocyte percentage decreased, recovered, exceeded the normal range, and returned to normal. Furthermore, the bone marrow mononuclear cell counts decreased sharply, decreased to the minimum value after 7 d post-irradiation, and gradually recovered. The monophyletic cloning ability of irradiated mouse bone marrow nuclear granulocytes also decreased significantly.
    Conclusion 6 Gy 137Cs γ-irradiation could cause changes in the peripheral blood of mice and inhibit the proliferation of hematopoietic progenitor cells.
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