Jicong Gui, Xingdang Liu. Development in the study of radium-223 chloride for treating castration-resistant prostate carcinoma with bone metastases[J]. Int J Radiat Med Nucl Med, 2015, 39(3): 268-272. DOI: 10.3760/cma.j.issn.1673-4114.2015.03.018
Citation: Jicong Gui, Xingdang Liu. Development in the study of radium-223 chloride for treating castration-resistant prostate carcinoma with bone metastases[J]. Int J Radiat Med Nucl Med, 2015, 39(3): 268-272. DOI: 10.3760/cma.j.issn.1673-4114.2015.03.018

Development in the study of radium-223 chloride for treating castration-resistant prostate carcinoma with bone metastases

  • Prostate carcinoma rates and mortalities are increasing worldwide. The therapeutic landscape of castration-resistant prostate carcinoma(CRPC) has changed rapidly. Radium-223 chloride, which is a radiopharmaceutical agent, targets bone metastasis by emitting high-energy alpha-particles with extremely short range(< 100 μm). This chemical is effective in reducing mortality without increasing toxicity. Thus, this agent has the potential to become a new alternative for treating patients with CRPC. The Food and Drug Administration approved radium-223 dichloride for treating patients with CRPC, symptomatic bone metastases, and unknown visceral metastatic disease in 2013. Therefore, combination and sequencing strategies will be future research directions.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return