Rongfu Wang. Progress and prospect of molecular probes of radionuclide tracing targeted tumor angiogenesis[J]. Int J Radiat Med Nucl Med, 2015, 39(1): 50-54. DOI: 10.3760/cma.j.issn.1673-4114.2015.01.011
Citation: Rongfu Wang. Progress and prospect of molecular probes of radionuclide tracing targeted tumor angiogenesis[J]. Int J Radiat Med Nucl Med, 2015, 39(1): 50-54. DOI: 10.3760/cma.j.issn.1673-4114.2015.01.011

Progress and prospect of molecular probes of radionuclide tracing targeted tumor angiogenesis

  • Tumor is hazard to human health and lives. Early diagnosis and treatment of tumor can obviously prolong patient survival time and improve the quality of life. At present, targeting diagnosis and therapy catch attention of researchers from all over the world. Peptide arginine-arginine-leucine(RRL)sequence is specific targeted to tumor-derived endothelial cell. Our team confirmed that the 131I-RRL had the effect of killing tumor cells, and 99Tcm-RRL could image tumors in different tumor models. Foreign scholars have already put the small molecules arginine-arginine-leucine targeting tumor angiogenesis in the preclinical stage.
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