The application of dynamic contrast-enhanced magnetic resonance imaging in early-phase clinical trials of antivascular medicine for malignant tumors

The development and research of antivascular medicine has already exerted challenges for traditional clinical trials and its evaluation system.Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI), as an uninvasive method to visualize and assess vascular structure and function, has been gradually utilized in clinical trials of antivascular medicine and improving stepwise with a view to further detecting angiogenesis of tumor and effects of medicine.This review will articulate on defects of traditional evaluation system in clinical trials of antivascular medicine, technological characteristics of DCE-MRI as well as pros and cons of its application in clinical trials.The detailed utilization of DCE-MRI in some early phase clinical trials during recent years will also be orchestrated in this review.