Xiaodong Zhang, Jie Chen, Di Wu, Xiu Shen, Shasha Song, Wei Long, Hao Wang, Peixun Liu, Saijun Fan, Yuanming Sun. Effect of Au nanoparticles modified with sulfhydryl-polyethylene glycol on liver cancer cell proliferation and radiation damage[J]. Int J Radiat Med Nucl Med, 2014, 38(3): 157-160, 189. DOI: 10.3760/cma.j.issn.1673-4114.2014.03.004
Citation: Xiaodong Zhang, Jie Chen, Di Wu, Xiu Shen, Shasha Song, Wei Long, Hao Wang, Peixun Liu, Saijun Fan, Yuanming Sun. Effect of Au nanoparticles modified with sulfhydryl-polyethylene glycol on liver cancer cell proliferation and radiation damage[J]. Int J Radiat Med Nucl Med, 2014, 38(3): 157-160, 189. DOI: 10.3760/cma.j.issn.1673-4114.2014.03.004
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Effect of Au nanoparticles modified with sulfhydryl-polyethylene glycol on liver cancer cell proliferation and radiation damage

    Abstract
  • Objective Au nanoparticles(AuNPs)was chemically modified with sulfhydryl-polyethylene glycol(SH-PEG) and its effects on liver cancer cell survival and radiation damage were assessed.
    Methods PEG-AuNPs were chemically fabricated with SH-PEG and AuNPs. The size of PEG-AuNPs and uptake by liver cancer cell were observed by field-emission transmission electron microscopy(TEM). The Cell Titer-Glo luminescent cell viability assay and cell colonies were used to examine effect of PEG-AuNPs on liver cancer cells′ survival and radiation damage.
    Results 14.4 nm and 30.5 nm PEG-AuNPs were obtained by above fabrication. 30.5 nm PEG-AuNPs were presented more absorption, inhibition the survival and enhance radiation effect to liver cancer cell.
    Conclusions After modification with SH-PEG, larger PEG-AuNPs with 30.5 nm showed stronger inhibition in liver cancer cellular survival and promoted liver cancer cells sensitive to radiation.
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