Protective effect of P-methyl cinnamic paeonol esters against radiation damage

Objective To study the radiaition protective effect of P-methyl cinnamic paeonol esters on irradiated mice.

Methods ICR mice of age 6-8 weeks were selected as investigated subjects, then the mice whole body were irradiated with 6.5 Gy or 8.5 Gy¹³⁷Cs γ-ray. The 30-day survival rates, organ indexes, superoxide dismutase(SOD)and malondialdehyde levels in lung and liver were observed to evaluate the radiation protective effect of P-methyl cinnamic paeonol esters in high, medium, low dose groups.

Results P-methyl cinnamic paeonol esters increased the 30-day survival rates of 8.5 Gy whole body irradiated mice. And after 6.5 Gy whole body irradiation, P-methyl cinnamic paeonol esters could enhance the platelet counts, DNA levels and thymus, spleen index. Meanwhile, SOD levels were increased with the increasing dose of P-methyl cinnamic paeonol esters, while malondialdehyde levels were decreased, especially in the high dose group.

Conclusion P-methyl cinnamic paeonol esters may play an important role in radiation resistance.