¹⁸F-FDG PET-CT imaging in the detection of recurrent and metastasis ovarian cancer

Objective To investigate the value of ¹⁸F-FDG PET-CT in the detection and diagnosis of recurrent and metastasis ovarian cancer.

Methods Retrospective analysis of whole body PET-CT imaging data of 65 patients after operation for ovarian cancer. All the case were followed-up for 3-57 months. The diagnosis was confirmed by surgical pathological examination, imaging studies and clinical follow-up.

Results Of the 65 patients, 55 cases developed tumor recurrence and metastasis, and 10 patients didn't show tumor recurrence and transfer. Of the 180 positive lesions displayed on ¹⁸F-FDG PET-CT images, 165 lesions were finally diagnosed as recurrence and metastasis, the remaining 15 lesions were identified as lymph node reactive hyperplasia. With ¹⁸F-FDG PET-CT, the accurate diagnosis were given in 60 patients(positive in 51 cases and negative in 9 cases), 1 given false positive diagnosis, and 4 cases of false negative diagnosis. As a result, the sensitivity, specificity, accuracy, positive-predictive value and negative-predictive value for detecting the ovarian lesions by ¹⁸F-FDG PET-CT were 92.7%(51/55), 90.0%(9/10), 93.8%(61/65), 98.1%(51/52), 69.2%(9/13)respectively. Carbohydrate antigen 125(CA125)levels had a positive relationships with the results of ¹⁸F-FDG PET-CT. The level of CA125 was increased in 47 cases, and positive images were found in 45 cases, the positive rate was 95.7%.

Conclusion ¹⁸F-FDG PET-CT has a high sensitivity and accuracy in the detection of recurrent and metastasis ovarian cancer. It is recommend to perform ¹⁸F-FDG PET-CT, in particular when elevated CA125 is detected.