Shen GUO, Guo-bao CHEN, Hong-feng DAI, Mei-fu LIN, Wen-xin CHEN. Automated synthesis of the estrogen receptors imaging agent 18F-FES[J]. Int J Radiat Med Nucl Med, 2011, 35(1): 41-44. DOI: 10.3760/cma.j.issn.1673-4114.2011.01.012
Citation: Shen GUO, Guo-bao CHEN, Hong-feng DAI, Mei-fu LIN, Wen-xin CHEN. Automated synthesis of the estrogen receptors imaging agent 18F-FES[J]. Int J Radiat Med Nucl Med, 2011, 35(1): 41-44. DOI: 10.3760/cma.j.issn.1673-4114.2011.01.012

Automated synthesis of the estrogen receptors imaging agent 18F-FES

  • Objective 18F-16α-17β-fluoroestradiol(18F-FES), an estrogen receptors imaging agent, is synthesized with Tracerlab FXFNsystem.
    Methods 18F-FES is obtained by two steps reactions, including the nucleophilic displacement reaction of no-carrier-added18F-fluoride with 3-O-methoxymethyl-16, 17-O-sulfuryl-16-epiesteriol, then the intermediate is evaporated and hydrolyzed with HCl and finally gives18F-FES.
    Results The synthesis of18F-FES can be completed in about 80 min.The radiochemical yield and radio-chemical purity are about 10%and 95%respectively.
    Conclusion The procedure ofsynthesis is simple and automatical.18FFES has an extremely lowtoxicity, which suggests that18F-FES may be a safe and effective estrogen receptors imagingagent.
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