Hai-qing XU, Jun DUAN, Bian WU. Study of relationship between the bone imaging, level of PSA and pathology grade in diagnosis of prostate carcinoma bone metastasis[J]. Int J Radiat Med Nucl Med, 2011, 35(1): 34-37. DOI: 10.3760/cma.j.issn.1673-4114.2011.01.010
Citation: Hai-qing XU, Jun DUAN, Bian WU. Study of relationship between the bone imaging, level of PSA and pathology grade in diagnosis of prostate carcinoma bone metastasis[J]. Int J Radiat Med Nucl Med, 2011, 35(1): 34-37. DOI: 10.3760/cma.j.issn.1673-4114.2011.01.010
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Study of relationship between the bone imaging, level of PSA and pathology grade in diagnosis of prostate carcinoma bone metastasis

    Abstract
  • Objective To investigate the relationship between the level of serum prostate-specific antigen(PSA), pathology grade and bone imaging in diagnosis of bone metastasis in prostatic carcinoma.
    Methods Serum PSA, whole body bone imaging with99Tcm-methylene diphosphonate, pathology grade in 107 cases of prostatic carcinoma were retrospectively reviewed as to their correlation with bone metastasis.
    Results Fourty-nine of 107 cases demonstrated bone metastasis by whole body bone imaging.There were significant difference in bone metastasis incidence rate among high differentiation group, middle differentiation group and low differentiation group.The results showed that when PSA < 20 μg/L, the possibility of bone metastasis was extremely low and follow-up studies were reuired.When serum PSA > 20 μg/L, bone metastasis should be considered and bone imaging was necessary.
    Conclusions There were some relationship among the level of PSA, pathology grade and bone metastasis.The possibility of bone metastasis became high when PSA > 20 μg/L.If PSA > 60 μg/L, a clinical diagnosis of bone metastasis might be made.
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