Yong-yi LU, Qun CHEN, Yong-qing YANG. Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension[J]. Int J Radiat Med Nucl Med, 2010, 34(5): 294-296. DOI: 10.3760/cma.j.issn.1673-4114.2010.05.011
Citation: Yong-yi LU, Qun CHEN, Yong-qing YANG. Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension[J]. Int J Radiat Med Nucl Med, 2010, 34(5): 294-296. DOI: 10.3760/cma.j.issn.1673-4114.2010.05.011
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Application of determination of PRA, Ang Ⅱ and IGF-1 levels in the study of typing of essential hypertension

    Abstract
  • Objective To study the clinical application of determination of plasma renin activity(PRA), Angiotensin Ⅱ (Ang Ⅱ)and insulin-like growth factor-1(IGF-1)levels in typing of essential hypertension(EH).
    Methods Determined the levels of PRA and Ang Ⅱ in 256 patients with EH and 70 healthy volunteers(as control group)by radioimmunoassay, and measured IGF-1 level by enzyme immunoassay.Research on the typing of EH and the difference between the groups.
    Results The PRA and Ang Ⅱ in control group was(0.432±0.236)μg·L-1·h-1 and (31.7±7.4)μg/L respectively.In 256 patients with EH,PRA was increased, normal and decreased in 18.0%, 71.8% and 10.2% respectively, while the level of Ang Ⅱ was increased, normal and decreased in 12.9%, 76.2% and 10.9% respectively.The IGF-1 levels in 256 patients with EH were increased following the increase of blood pressure.
    Conclusion Typing of EH patients with PRA and Ang Ⅱ as well as the determination of IGF-1 were useful in treating and following up the patients with EH.
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