Xin XI, Han-ying LIU, Xian-zao XU, Ji-hua ZHU. Study on radioprotective effect of Wu-He Dipsacus asper in mice[J]. Int J Radiat Med Nucl Med, 2010, 34(2): 116-119. DOI: 10.3760/cma.j.issn.1673-4114.2010.02.016
Citation: Xin XI, Han-ying LIU, Xian-zao XU, Ji-hua ZHU. Study on radioprotective effect of Wu-He Dipsacus asper in mice[J]. Int J Radiat Med Nucl Med, 2010, 34(2): 116-119. DOI: 10.3760/cma.j.issn.1673-4114.2010.02.016
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Study on radioprotective effect of Wu-He Dipsacus asper in mice

    Abstract
  • Objective To study protective effect of Wu-He Dipsacus asper(WHDA)injection on the radiation damaged mice.
    Methods One hundred and twenty Kunming female mice were divided into normal control group, model control group, Wu-He Dipsacus asper treatment group to observe the 30-day survival rate; measured peripheral blood 6 hours, 3 days, 6 days and 9 days after irradiation, respectively; thymus, spleen and liver weight were detected; superoxide dismutase(SOD), glutathione(GSH), malonyldialdehyde(MDA)in liver and peripheral blood were also detected.
    Results WHDA can improve the survival rate of mice after radiation, and take a significant influence on white blood cells and platelets, but no obvious effect on the weight of thymus, spleen and liver.In addition, WHDA can improve SOD activity, increased GSH content and decrease MDA content significantly in this study.
    Conclusion WHDA has obvious protective effect in mice with radiation injury.
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