Nuclear medicine diagnostic experience for 25 patients with parathyroid disease accompanied elevated serum PTH level

Objective To explore nuclear medicine diagnostic method for parathyroid disease accompanied elevated serum parathyroid hormone(PTH)level.

Methods The images of 25 patients with parathyroid disease were obtained by SPECT⁹⁹Tc^m-MIBI double-phase parathyroid imaging and ⁹⁹Tc^mmethylene diphosphonate(⁹⁹Tc^m-MDP)whole-body static bone imaging.All subject were measured serum PTH, calcium, phosphorus and alkaline phosphatase.

Results ① Serum PTH level increased to varying degrees in patients with primary hyperparathyroidism(PHPT), secondary hyperparathyroidism(SHPT).②PHPT and SHPT showed significant change before and after surgery(t=6.24 and t=6.85, P < 0.01).③The whole-body static bone images of PHPT patients were characterized by metabolic bone disease images.The positive rates of ⁹⁹Tc^m-MIBI were above 90%.④Whole-body bone imaging results of SHPT patients showed complex and diverse caused by high background, increased uptakes mainly. ⁹⁹Tc^m-MIBI dual-phase parathyroid imaging showed hyperparathyroidism in varying degree, up to 56%or more.

Conclusion Determination of serum PTH combined SPECT for parathyroid and whole-body bone imaging showed high clinical value in diagnosis and treatment of parathyroid disease.