Effects of ¹²⁵I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells

Continuous irradiation of low dose rate ¹²⁵I seed resulted in an increase in the apoptosis and an increased expression of Bax and a decreased expression of Bcl-2. The cell-cycle arrest of hepatoma carcinoma cells was induced remarkably. The results demonstrated that low dose rate of continuous ¹²⁵I seed irradiation is effective on inducing the damage-of the tumor cells.