JIA Li-li, FAN Fei-yue. Gadd45 and genomic stability[J]. Int J Radiat Med Nucl Med, 2009, 33(2): 105-109. DOI: 10.3760/cma.j.issn.1673-4114.2009.02.013
Citation: JIA Li-li, FAN Fei-yue. Gadd45 and genomic stability[J]. Int J Radiat Med Nucl Med, 2009, 33(2): 105-109. DOI: 10.3760/cma.j.issn.1673-4114.2009.02.013

Gadd45 and genomic stability

  • Gadd45 gene is one of growth arrest and DNA damage-inducible(Gadd)family.It's also a gene induced by ionization radiation.It plays an important role in controlling cell cycle,repairing damaged DNA and in cell apoptosis.This makes it work as an improtant gene in mainteining genomic stability.but more importantly it induces cell apoptosis and is a bridge in the cascade process of apoptosis of tumor cell.At the same time,it takes part in tumorigenesis.
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