Objective To analyze the glucose metabolism of right ventricle between patients with idiopathic pulmonary arterial hypertension (IPAH) and patients with pulmonary arterial hypertension related to congenital heart disease (PAH-CHD).
Methods From November 2016 to December 2018, 26 patients with IPAH (the IPAH group) (17 females, 9 males, 28.23±8.92 years old) and 16 patients with PAH-CHD (the PAH-CHD group) (10 females, 6 males, 29.19±10.62 years old) diagnosed in Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College were enrolled and underwent dynamic 18F-FDG PET myocardial metabolic imaging. The rate of myocardium glucose utilization (rMGU) of both the right and left ventricles was quantified via Patlak analysis. Within 1 week, right heart catheterization was performed in all subjects to evaluate pulmonary hemodynamic parameters. rMGU and other parameters were compared via independent sample t test. The relationship between rMGU and pulmonary vascular resistance and mean pulmonary artery pressure (mPAP) in the two groups of patients was analyzed via Pearson correlation analysis.
Results No significant difference in mPAP was observed between patients in IPAH group and PAH-CHD group ((59.85±16.46) mm Hg) vs. (69.75±18.93) mm Hg, t=1.79, P=0.81) (1 mm Hg=0.133 kPa). The right ventricular rMGU of patients in PAH-CHD group was not significantly different from that of patients in IPAH group ((0.135±0.165) μmol·g−1·min−1 vs. (0.095±0.074) μmol·g−1·min−1, t=1.07, P=0.29). Similarly, the left ventricular rMGU between the former ((0.070±0.047) μmol·g−1·min−1) and the latter ((0.057±0.065) μmol·g−1·min−1) was not significantly different (t=0.77, P=0.49). The right ventricular rMGU was significantly correlated with mPAP in patients with IPAH (r=0.420, P=0.033), but not in patients with PAH-CHD (r=0.016, P=0.953).
Conclusion In patients with PAH-CHD and IPAH with no difference in mPAP, no significant difference in rMGU was found in both the right ventricles.
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