2019 Vol. 43, No. 4
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2019, 43(4): 295-302.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.001
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Abstract:
Objective To explore the clinical value of 18F-FDG PET/CT-related parameters for the prediction of tumor disease-free survival time (DFS) and overall survival time (OS) after the radical resection of colorectal cancer (CRC). Methods Retrospective analysis was conducted on 132 patients (93 males and 39 females; median age, 63 years) with CRC who underwent 18F-FDG PET/CT examination between November 2011 and October 2016. The 18F-FDG PET/CT-related parameters were as follows: SUVmax=2.5 (20%, 30%, 40%, and 50% of SUVmax were used as different thresholds); SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of different thresholds; and DFS and OS of CRC patients after radical resection. The receiver-operating characteristic (ROC) curve was used in the measurement of the area under curve of 18F-FDG PET/CT-related parameters and the optimal DFS cutoff value. Survival analysis was performed with the Kaplan-Meier method. Univariate and multivariate analyses were performed with Log-rank test and the COX proportional hazards model, respectively. Results The ROC curve predicted the DFS cut off value, and SUVmax=19.36, MTV= 22.64 cm3, TLG= 117.78 g, TLG20% = 129.74 g, TLG30% = 107.05 g, TLG40% = 73.22 g, and TLG50% = 56.13 g. DFS univariate analysis showed that CEA, CA19-9, lymph node metastasis, clinical stage, chemotherapy, SUVmax, MTV, TLG, TLG20%, TLG30%, TLG40%, and TLG50% were the factors influencing postoperative DFS. Multivariate analysis showed that SUVmax (95%CI: 1.882–5.815, OR= 3.308, P<0.000), clinical stage (95%CI: 1.226–3.819, OR = 2.164, P=0.008), and CA19-9 (95%CI: 1.182–3.724, OR=2.098, P= 0.011) were independent risk factors for postoperative DFS. The survival analysis of OS univariate analysis showed that CEA, CA19-9, histological type, SUVmax, MTV, TLG, TLG20%, TLG30%, TLG40%, and TLG50% were the factors influencing postoperative OS. Furthermore, SUVmax (95%CI: 1.129–6.624, OR=2.735, P=0.026), TLG50% (95%CI: 1.640–19.801, OR=5.699, P=0.006), and CA19-9 ( 95%CI: 1.868–11.084, OR=4.550, P=0.001) were the independent risk factors for postoperative OS. Conclusion 18F-FDG PET/CT-related parameters SUVmax and TLG50% can predict the prognosis of patients with CRC; the higher the parameter values are, the worse the prognoses are.
2019, 43(4): 303-307.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.002
Abstract:
Objiective To compare the diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT and 99Tcm-methylene diphosphonic acid (99Tcm-MDP) SPECT whole body bone scan in detecting of multiple myeloma bone disease (MBD). Methods The retrospective study enrolled 18 male and 11 female multipe myeloma (MM) patients, aged 39-81 years (mean, 60.14±10.41 years) and clinically diagnosed from April 2015 to May 2018 in Anqing hospital affiliated to Anhui medical university. 18F-FDG PET/CT and 99Tcm-MDP SPECT were performed two weeks apart, and χ2 test was used in comparing abnormal bone changes detected by 18F-FDG PET/CT and 99Tcm-MDP SPECT. Results 18F-FDG PET/CT and 99Tcm-MDP SPECT accurately diagnosed 28 and 21 MM patients, respectively. Eighteen patients were focal, one patient was diffuse, and nine patients were mixed on the 18F-FDG PET/CT images. Twenty-one MM patients were found single, that is, multiple bones accumulated the agent abnormally on 99Tcm-MDP SPECT images. The positive match rate of 18F-FDG PET/CT and 99Tcm-MDP SPECT were 96.6% (28/29) and 72.4% (21/29), respectively. The differences between the sensitivities of the two methods were significant. Conclusion The results indicate that 18F-FDG PET/CT is more sensitive than 99Tcm-MDP SPECT in detecting MBD in patients with MM and has a significant diagnostic value for bone marrow involvement and extramedullary disease.
2019, 43(4): 308-313.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.003
Abstract:
Objective To investigate the predictive value of postoperative initial stimulated thyroglobulin(ps-Tg) level on the distant metastasis of differentiated thyroid carcinoma(DTC). Methods A total of 113 patients who suffered from DTC and underwent first radioactive iodine(RAI) therapy from August 2016 to August 2017 were identified. Of these patients, 32 were males and 81 were females. Their ages ranged from 15 years to 68 years (44.85±12.01 years). The patients were classified into a non-distant metastasis(M0) group and a distant metastasis(M1) group. The biochemical parameters of thyroid function and thyroid antibodies were evaluated after 4 weeks of levothyroxine withdrawal. After RAI therapy, whole body imaging and local SPECT/CT were performed. The basic data of the two groups were compared via a chi-square test, Student's t test, and a Mann-Whitney rank-sum test. ps-Tg values between M0 and M1 were also compared via the Mann-Whitney rank-sum test. An receiver operating characteristic(ROC) curve was drawn and analyzed to evaluate the predictive value of ps-Tg, and a diagnostic critical point(DCP) was obtained. Results Differences in pathological type, cervical lymph node metastasis, and RAI dose were observed between M0(85 cases) and M1(28 cases) (χ2=12.588, 12.588, 12.581; P=0.003, 0.003, 0.002). No significant differences were found in gender, age, tumor stage, and time from surgery to the first measurement of Tg, TSH, and TgAb between the two groups. The mean values M(P25~P75) of ps-Tg levels in the two groups were 1.95(0.70–6.98) and 95.05 (6.98–278.47) ng/mL. A significant difference was present between the two groups(U=417.5, P=0.000). The area under the ROC curve of ps-Tg levels was 0.825(95%CI: 0.713–0.936), with a sensitivity of 71.4%, a specificity of 91.8%, and an accuracy of 86.7%. The cut-off value of DCP was 28.80 ng/mL. Conclusion The initial ps-Tg level is a meaningful indicator for predicting the distant metastases of DTC.
2019, 43(4): 314-319.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.004
Abstract:
Objective To observe the CT and MRI results of solitary fibrous tumors(SFT) in the abdomen and pelvis, analyze their characteristic imaging, and improve the accuracy of diagnosis and understanding of the disease. Methods Retrospective analysis of 18 cases confirmed by pathology from January 2008 to June 2017[9 men, 9 women, age 41–71(53.0±10.6) years old] through imaging findings and clinical and pathological data of patients with pelvic SFT. Among the 18 patients, 13 received dynamic CT and 5 received dynamic MRI. The tumor size(maximum diameter), morphology, density or signal, dynamic enhancement characteristics, arterial tumor vessels, and tumors were mainly analyzed. Fisher's exact test was conducted to examine the relationship between tumor size, boundary, and morphology of benign and malignant tumors. The differences among the three characteristics in malignant tumors were determined by Fisher' s test. Results ① Characteristics of CT imaging: The maximum diameter of tumor lesions in the 13 patients with CT was(2.7–23.4) cm, and the mean diameter was(10.53±6.21) cm. Among the 13 cases, 8 were lobulated and 7 exhibited cystic degeneration. One patient showed calcification. Furthermore, 11 cases of nonuniform enhancement by dynamic enhancement was observed. Delayed enhancement was observed in 8 cases. Mild to moderate enhancement was observed in 2 cases. In 10 cases, pointy and linear enhancement of vessels could be seen at the arterial stage, and in 8 cases, tortuous vessels were observed around the lesions. The maximum diameter of the lesions was (10.0–13.4) cm and the mean diameter was(11.93±3.21) cm. ② Characteristics of MRI: The lesion boundaries of 5 patients were clear, and the lesions were lobulated in 4 of 5 patients. In T2 weighted imaging, cystic changes were observed in 3 patients. In 4 cases, scarlike or flaky low-signal areas were found in the lesions, 1 case showed uniform isobaemic signals, and 5 cases presented empty vascular shadows. Moreover, 4 cases indicated an obvious uneven enhancement. Delayed enhancement was observed in 4 cases, and uniform enhancement was observed in 1 case. In 5 cases, vessels were strengthened in the lesion at the arterial stage. ③ Pathology results showed that among the 18 SFT cases, 7 were malignant and 11 were benign. For the malignant SFT, 5 of 7 cases exceeded the average diameter[(10.88±5.62) cm], whereas for the benign SFT, only 2 of 11 cases exceeded the mean. The maximum diameter was different between the benign and malignant lesions(χ2=5.103, P=0.039), showing statistical significance. Conclusions Although radiological findings on abdomino-pelvic SFT vary between dynamic contrast enhanced CT and MRI, a hypervascular mass with delayed enhancement is the imaging feature. Peripheral tortuous vessels and filiform vessels in the lesion may reinforce the diagnosis. The low signal of T2 weighted imaging in MRI also has a certain diagnostic value.
2019, 43(4): 320-326.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.005
Abstract:
Objective To investigate the imaging features and clinical significance of radionuclide cisternography(RNC) in patients with spontaneous intracranial hypotension(SIH). Methods Lumbar puncture was made on 19 patients with SIH(4 males and 15 females), and 99Tcm-DTPA was injected into their spinal subarachnoid space. Multitemporal RNC was also performed. SPECT/CT tomography and MRI were added to examine abnormal distribution, and RNC image features were comprehensively analyzed. χ2-test was conducted to compare the enumeration data between groups. Results RNC could be applied to diagnose SIH by showing direct signs such as spinal cord or nasal cerebrospinal fluid leak points or by revealing the abnormal circulation of the cerebrospinal fluid (CSF), such as a slow increase in imaging agents; difficulty in reaching the cistern, the cerebral convex surface, and the superior sagittal sinus; and early imaging of the bladder and the kidney. RNC could also be used to detect the CSF leaks in 17 cases and reveal a direct sign of CSF leaks in 12 cases. Its detection rate was 63.2%. Of these cases, 9 were located in the cervicothoracic junction or the thoracic region, 1 was found in the lumbar, and 2 were observed to have CSF rhinorrhea. A case of high-flow CSF leakage (lumbar segment) occurred in 1 patient. When conservative treatment was ineffective, the patients were treated with targeted epidural blood patch. Two more cases had a normal RNC. A comparison of the MRI findings of 17 patients showed no significant differences between MRI (positive rate of 58.8% [10/17]) and RNC (positive rate of 88.2% [15/17]) in the diagnosis of low intracranial pressure (P > 0.05). However, RNC was superior to MRI in detecting CSF leakage. Of the 12 cases subjected to RNC, only 1 case was found to have CSF leaks through MRI. Conclusions RNC can help diagnose SIH by determining direct or indirect signs and is superior to MRI in terms of detecting CSF leakage. RNC can also be used to show the amount of CSF leakage and facilitate individualized treatment, which is important for the diagnosis and treatment of SIH．
2019, 43(4): 327-333.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.006
Abstract:
Objective This study aims to investigate the MRI appearance and diagnostic value of the posterior horn of the lateral meniscus (PHLM) tear of the knee ligament attachment zone. Methods From December 2012 to June 2018, 35 patients with anterior cruciate ligament (ACL) injury combined with PHLM tear in the knee ligament attachment zone were selected as the observation group. Thirty patients with ACL injury but without PHLM tears were collected as the control group A. Another 30 healthy people who received routine physical examination were selected as the control group B. All subjects received knee MRI examination. The MRI performance of all subjects in the three groups was observed. χ2 test, one-way ANOVA, and t-test were used to calculate the incidence of knee MRI signs, the damage of the structure around the knee joint, and the number and length of the linear high-signal images of the knee joint. The receiver operating characteristic curve was used to analyze the effectiveness of differential diagnosis of true and false tear in PHLM. Results Patients in the observation group showed significant linear hyperintense on the MRI sagittal plane and cross-sectional images. The sagittal plane was continuously detected (5.75±1.38) layers (called "continuous line sign"), extending from the inside to the outside (15.06 ± 5.02) mm (called "zipper sign"). The number of layers on the sagittal plane and the length of the transverse section in the observation group were higher than those in the control groups A and B ( F =43.231, 36.113, both P < 0.05). Combined with "continuous line sign" and "zipper sign" as the positive criteria, the sensitivity was 85.71%, the specificity was 95%, and the accuracy was 91.58%. Conclusion The PHLM tear in the knee ligament attachment zone had obvious signs on MRI, supplemented by "continuous line sign" and "zipper sign" for differential diagnosis, which could significantly improve the diagnostic effect.
2019, 43(4): 334-339.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.007
Abstract:
Objective To survey and analyze the environmental gamma radiation level and the status of birth defects among perinatal infants in Huizhou within 50 km away from the Guangdong Daya Bay Nuclear Power Station(GNPS). Methods Unit 1 of GNPS was taken as the center of the circle and divided into four circular investigation areas with radii of 0–20 km, 20–30 km, 30–40 km, and 40 –50 km(each interval excluded the lower boundary). Data on the accumulated doses of environmental gamma radiation and the status of birth defects among perinatal infants in each investigation area from 2015 to 2017 were collected, and the birth defect rate of perinatal infants and the top five birth defects in Huizhou among different years and within different ranges around GNPS were analyzed. Analysis of variance was used to compare the differences in accumulated dose of the environmental gamma radiation among various distances, and Chi-square test was used to compare the differences in birth defect rate among various years and various distances. Results The annual accumulated dose of environmental gamma radiation was(2.00±0.20) mSv from 2015 to 2017 and did not vary among different investigation areas. Out of the 58,999 perinatal infants, 691 were born with birth defects. The total incidence of birth defects was 11712 per million. The incidence of birth defects varied from year to year. Specifically, the lowest rate was found in 2015(7486 per million), whereas the highest rate was observed in 2017(13992 per million). Significant difference in birth defect rate was observed among different years(χ2=35.807, P=0.000). The incidence of birth defects was different among various investigation areas within the distance from the nuclear power plant. In particular, the highest birth defect rate was found at 40 –50 km(15881 per million), whereas the lowest birth defect rate was observed at 30 –40 km(8056 per million). Significant differences in birth defect rate was also observed among the investigation areas(χ2=63.622, P=0.000). The top five detected birth defects were polydactyly(114 cases), congenital heart defects(102 cases), glucose-6-phosphate dehydrogenase deficiency(75 cases), talipes equinovarus(31 cases), and hydrops fetalis syndrome(23 cases). Conclusions Within 50 km around GNPS, the environmental gamma radiation level and the birth defect rate were stable and consistent with the average level in Guangdong. Moreover, the changes in birth defect rate and sequence were spontaneous.
2019, 43(4): 340-348.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.008
Abstract:
Objective To investigate differentially regulated genes after whole thoracic X-ray exposure and to explore the potential gene markers at transcriptome levels of radiation-induced lung injury (RILI) at transcriptome levels in mice. Methods A total of 96 C57BL6 female mice aged 8 weeks were divided into three groups by single X-ray irradiation, namely. control group (no irradiation), medium dose group (MD group, 10 Gy single irradiation), and high dose group (HD group, 20 Gy single irradiation). Whole thoracic X-ray irradiation was delivered to the remaining 60 mice with a wide range of doses and fractionations. Whole genome expression chips were used in the detection of RNA in mouse lung tissues and gene expression data were converted by the R language software. Classical Bayesian test was used in exploring differentially expressed genes between groups. The expression levels of key genes were validated and mathematically analyzed, and gene ontology biological function enrichment analysis was performed. The correlation degree between two groups with independent data was analyzed by regression model (correlation coefficient is R2). Results According to medium vs. high dose irradiations, the differentially regulated genes(539 genes) were selected. Then, the top five most significant genes were identified, namely, Phlda3, Fgg, Kng1 (up-regulated genes) and Ptprb, Kit (down-regulated genes). Dose escalation studies confirmed that the transcriptional status of the five gene signatures correlated well with radiation doses. The expression levels of the three up-regulated genes increased with the boost of X-ray dose (logistic regression model χ2=11.66, R2=0.88); whereas the expression levels of the two down-regulated genes decreased with the boost in X-ray dose (linear regression R=−0.95, R2=0.89). Gene set enrichment analysis revealed that up-regulated genes were associated with p53 signaling and innate immune response; whereas the down-regulated genes were enriched in biological processes, such as cell metabolism and lung development. Conclusions Up-regulated genes Phlda3, Fgg, Kng1, as well as the down-regulated genes, Ptprb and Kit, can be used as potential genetic markers to indicate the severity of RILI. This finding sheds light on the mechanism involved in the radiation protection evidenced by mRNA biomarkers.
2019, 43(4): 349-355.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.009
Abstract:
Pharmacokinetics is an important part of pharmacology, which is guide for drug using rationally, preventing adverse reactions, studying the mechanism of action and drug-drug interaction. PET molecular imaging technology is able to dynamically monitor physiological, biochemical and biological processes in vivo, and it can be applied to the study of pharmacokinetics, tissues distribution and drug-drug interaction. All of these will promote new drug development. This paper summarizes the applications of PET molecular imaging technology to pharmacokinetics in recent years.
Pharmacokinetics is an important part of pharmacology, which is guide for drug using rationally, preventing adverse reactions, studying the mechanism of action and drug-drug interaction. PET molecular imaging technology is able to dynamically monitor physiological, biochemical and biological processes in vivo, and it can be applied to the study of pharmacokinetics, tissues distribution and drug-drug interaction. All of these will promote new drug development. This paper summarizes the applications of PET molecular imaging technology to pharmacokinetics in recent years.
2019, 43(4): 356-360.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.010
Abstract:
Programmed cell death-1 (PD-1) and its ligand (PD-L1) inhibitors can inhibit the PD-1 and PD-L1 combination to block negative control signals. This condition leadings to the activity of T lymphocytes and the enhancement of immune responses. Clinical studies have shown that PD-1/PD-L1 inhibitors have a definite effect on a broad set of malignancies, but a substantial number of patients do not respond. Predicting the immunotherapy response by evaluating the expression of PD-1 and PD-L1 is urgently needed. Molecular imaging modalities, such as PET, SPECT, optical imaging, and MRI, can noninvasively and dynamically detect the overall expression of PD-1/PD-L1 in patients. They can help in selecting patients who are suitable for immunotherapy and monitor the tumor response. This review describes the current status and progress of molecular imaging targeting PD-1/PD-L1 in tumors.
Programmed cell death-1 (PD-1) and its ligand (PD-L1) inhibitors can inhibit the PD-1 and PD-L1 combination to block negative control signals. This condition leadings to the activity of T lymphocytes and the enhancement of immune responses. Clinical studies have shown that PD-1/PD-L1 inhibitors have a definite effect on a broad set of malignancies, but a substantial number of patients do not respond. Predicting the immunotherapy response by evaluating the expression of PD-1 and PD-L1 is urgently needed. Molecular imaging modalities, such as PET, SPECT, optical imaging, and MRI, can noninvasively and dynamically detect the overall expression of PD-1/PD-L1 in patients. They can help in selecting patients who are suitable for immunotherapy and monitor the tumor response. This review describes the current status and progress of molecular imaging targeting PD-1/PD-L1 in tumors.
2019, 43(4): 361-366.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.011
Abstract:
Glioma is the most common intracranial tumor, accounting for 40%–55% of brain tumor cases. The time of diagnosis affects the prognosis of patients. The application of PET imaging agents, which is a noninvasive method of diagnosis, to glioma has increased rapidly in recent years. 18F fluorothymidine (18F-FLT) is a common PET imaging agent, which is a radioactive thymidine analog and is used to evaluate cell proliferation. This imaging agent can provide more information than that from other imaging examinations and agents during and after the treatment of glioma. In this review, we mainly discuss the present research status of glioma imaging agents in the brain, including the 18F-FLT imaging mechanism; the diagnosis, classification, and identification of recurrence and necrosis; the curative effect evaluation and prognosis of glioma from 18F-FLT; and the relationship between 18F-FLT and Ki-67.
Glioma is the most common intracranial tumor, accounting for 40%–55% of brain tumor cases. The time of diagnosis affects the prognosis of patients. The application of PET imaging agents, which is a noninvasive method of diagnosis, to glioma has increased rapidly in recent years. 18F fluorothymidine (18F-FLT) is a common PET imaging agent, which is a radioactive thymidine analog and is used to evaluate cell proliferation. This imaging agent can provide more information than that from other imaging examinations and agents during and after the treatment of glioma. In this review, we mainly discuss the present research status of glioma imaging agents in the brain, including the 18F-FLT imaging mechanism; the diagnosis, classification, and identification of recurrence and necrosis; the curative effect evaluation and prognosis of glioma from 18F-FLT; and the relationship between 18F-FLT and Ki-67.
2019, 43(4): 367-372.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.012
Abstract:
Thyroid cancer is an endocrine tumor with a rapid increase in prevalence in recent years. Human malignant tumors are closely related to environmental factors. Environmental changes can induce changes in certain pathogenic genes in the body, thus promoting the occurrence of diseases. A class of non-coding RNAs over 200 nucleotides in length, known as long non-coding RNAs(LncRNAs), has been found in human transcriptomes. LncRNAs are non-coding RNAs over 200 nucleotides in length that are involved in tumorigenesis, cell proliferation, proliferation, apoptosis, migration, and invasion by regulating gene expression. More and more studies have found that LncRNAs are closely related to thyroid cancer. Many LncRNAs have carcinogenic or tumor suppressive effects on the thyroid gland, but its function and mechanism are still unclear. This article reviews the recent research progress of LncRNAs in thyroid cancer, and provides a basis for exploring the mechanism of LncRNAs in thyroid cancer and its clinical application.
Thyroid cancer is an endocrine tumor with a rapid increase in prevalence in recent years. Human malignant tumors are closely related to environmental factors. Environmental changes can induce changes in certain pathogenic genes in the body, thus promoting the occurrence of diseases. A class of non-coding RNAs over 200 nucleotides in length, known as long non-coding RNAs(LncRNAs), has been found in human transcriptomes. LncRNAs are non-coding RNAs over 200 nucleotides in length that are involved in tumorigenesis, cell proliferation, proliferation, apoptosis, migration, and invasion by regulating gene expression. More and more studies have found that LncRNAs are closely related to thyroid cancer. Many LncRNAs have carcinogenic or tumor suppressive effects on the thyroid gland, but its function and mechanism are still unclear. This article reviews the recent research progress of LncRNAs in thyroid cancer, and provides a basis for exploring the mechanism of LncRNAs in thyroid cancer and its clinical application.
2019, 43(4): 373-380.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.013
Abstract:
Prostate cancer is one of the most common malignancies worldwide. Many advances have been made over the past years, but the treatment of metastatic prostate cancer remains challenging. In many cases, existing therapies have become ineffective for controlling tumor progression. Thus, new approaches are urgently needed. Radioligand therapy with 177Lu-Prostate specific membrane antigen (PSMA) is an innovative and effective therapy for patients with castration-resistant metastatic prostate cancer. PSMA is expected to be a standard regimen for prostate cancer as it is well tolerated by patients and has high potential for improving overall survival.
Prostate cancer is one of the most common malignancies worldwide. Many advances have been made over the past years, but the treatment of metastatic prostate cancer remains challenging. In many cases, existing therapies have become ineffective for controlling tumor progression. Thus, new approaches are urgently needed. Radioligand therapy with 177Lu-Prostate specific membrane antigen (PSMA) is an innovative and effective therapy for patients with castration-resistant metastatic prostate cancer. PSMA is expected to be a standard regimen for prostate cancer as it is well tolerated by patients and has high potential for improving overall survival.
2019, 43(4): 381-385.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.014
Abstract:
The author reported one case of 18F-FDG imaging combined with 18F fluorothymidine（18F-FLT） in the diagnosis of primary highly differentiated hepatocellular carcinoma. The characteristics of the disease were analyzed according to clinical symptoms, laboratory examinations, and radiology. The advantages of PET/CT in the diagnosis of liver diseases were expounded, and the deficiency of 18F-FDG in the diagnosis of liver cancer was indicated. The literature on the application of 18F-FLT 11C-acetate to hepatocellular carcinoma was reviewed. This study concluded that the combined use of different imaging agents is of great value in the diagnosis of liver-occupying lesions.
The author reported one case of 18F-FDG imaging combined with 18F fluorothymidine（18F-FLT） in the diagnosis of primary highly differentiated hepatocellular carcinoma. The characteristics of the disease were analyzed according to clinical symptoms, laboratory examinations, and radiology. The advantages of PET/CT in the diagnosis of liver diseases were expounded, and the deficiency of 18F-FDG in the diagnosis of liver cancer was indicated. The literature on the application of 18F-FLT 11C-acetate to hepatocellular carcinoma was reviewed. This study concluded that the combined use of different imaging agents is of great value in the diagnosis of liver-occupying lesions.
2019, 43(4): 386-388.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.015
Abstract:
Intestinal duplication is a rare congenital disease. Its clinical manifestations are nonspecific, and preoperative diagnosis is difficult. Gastrointestinal angiography, ultrasound, and CT are often used to detect this disease. A case of small intestinal duplication can be diagnosed through 99TcmO4− imaging. The advantages of this radionuclide imaging have been emphasized in literature. It can be used to diagnose intestinal duplication and help identify causes of lower gastrointestinal bleeding in children.
Intestinal duplication is a rare congenital disease. Its clinical manifestations are nonspecific, and preoperative diagnosis is difficult. Gastrointestinal angiography, ultrasound, and CT are often used to detect this disease. A case of small intestinal duplication can be diagnosed through 99TcmO4− imaging. The advantages of this radionuclide imaging have been emphasized in literature. It can be used to diagnose intestinal duplication and help identify causes of lower gastrointestinal bleeding in children.
2019, 43(4): 389-392.
doi: 10.3760/cma.j.issn.1673-4114.2019.04.016
Abstract:
The author reports two cases of unilateral absent pulmonary perfusion imaging. On the basis of clinical symptoms, laboratory tests, imaging examinations, and pulmonary angiography, the patients were diagnosed with pulmonary arteritis. Pulmonary perfusion imaging can be used as a good testing tool for pulmonary arteritis and has important significance in assessing disease severity and directing further management. This tool plays an irreplaceable role in follow-up and curative effect evaluation.
The author reports two cases of unilateral absent pulmonary perfusion imaging. On the basis of clinical symptoms, laboratory tests, imaging examinations, and pulmonary angiography, the patients were diagnosed with pulmonary arteritis. Pulmonary perfusion imaging can be used as a good testing tool for pulmonary arteritis and has important significance in assessing disease severity and directing further management. This tool plays an irreplaceable role in follow-up and curative effect evaluation.
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