2003 Vol. 27, No. 1
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2003, 27(1): 1-3.
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Abstract:
The categories, characteristics and consequences of terrorist incidents involving radioactive materials was introduced. The key functions of crisis and consequence management in the response of counter terrorism were also addressed. Meanwhile, the additional research and/or development needed for consequence management were noted, too.
The categories, characteristics and consequences of terrorist incidents involving radioactive materials was introduced. The key functions of crisis and consequence management in the response of counter terrorism were also addressed. Meanwhile, the additional research and/or development needed for consequence management were noted, too.
2003, 27(1): 4-8.
Abstract:
To evaluate the efficiency of gene therapy, it is requisite to monitor localization and expression of the therapeutic gene in vivo. Monitoring expression of reporter gene using radionuclide reporter gene technique is the best method. Adenoviral vectors expressing reporter gene are constructed using gene fusion,bicistronic,double promoter or bidirectional transcriptional recombination techniques, and transferred into target cells and tissues, then injected radiolabeled reporter probes which couple to the reporter genes. The reporter genes can be imaged invasively, repeatedly, quantitatively with γ-camera,PET and SPECT. Recently,several reporter gene and reporter probe systems have been used in studies of gene therapy. The part of them has been used for clinic trials.
To evaluate the efficiency of gene therapy, it is requisite to monitor localization and expression of the therapeutic gene in vivo. Monitoring expression of reporter gene using radionuclide reporter gene technique is the best method. Adenoviral vectors expressing reporter gene are constructed using gene fusion,bicistronic,double promoter or bidirectional transcriptional recombination techniques, and transferred into target cells and tissues, then injected radiolabeled reporter probes which couple to the reporter genes. The reporter genes can be imaged invasively, repeatedly, quantitatively with γ-camera,PET and SPECT. Recently,several reporter gene and reporter probe systems have been used in studies of gene therapy. The part of them has been used for clinic trials.
2003, 27(1): 8-10.
Abstract:
Hypoxic imaging can exhibit dysfunctional but viable tissues in organs. Autoradiographic imaging using hy-opxic marker can identify ischemic penumbra. Hyopxic tissue revealed by PET may represent the ischemic penumbra in patients presenting with acute cerebral infarction, and there are some correlation between hypoxic tissue volume and neurological and functional outcome.
Hypoxic imaging can exhibit dysfunctional but viable tissues in organs. Autoradiographic imaging using hy-opxic marker can identify ischemic penumbra. Hyopxic tissue revealed by PET may represent the ischemic penumbra in patients presenting with acute cerebral infarction, and there are some correlation between hypoxic tissue volume and neurological and functional outcome.
2003, 27(1): 11-13.
Abstract:
Small cell lung cancer is neuroendocrine neoplasm and origins from APUD (amine precursor uptake decarboxylation) cell. Somatostatin receptors (SSTR) are highly expressed on the surface of tumor cell. Octreotide is an analogue of somatostatin consisting of 8 amino acids, which with a similar bioactive structure not only has stronger biologic effect and longer biologic half life but also is less susceptible to degradation. Tumor receptor imaging with isotope labeled octreotide is a suitable noninvasive technique in the diagnosis of small cell lung cancer.
Small cell lung cancer is neuroendocrine neoplasm and origins from APUD (amine precursor uptake decarboxylation) cell. Somatostatin receptors (SSTR) are highly expressed on the surface of tumor cell. Octreotide is an analogue of somatostatin consisting of 8 amino acids, which with a similar bioactive structure not only has stronger biologic effect and longer biologic half life but also is less susceptible to degradation. Tumor receptor imaging with isotope labeled octreotide is a suitable noninvasive technique in the diagnosis of small cell lung cancer.
2003, 27(1): 14-16,20.
Abstract:
Fusion images of nuclear medicine and CT or MR have overcome the inherent limitations of both modalities, and valuable physiologic information was acquaired benefitting from a precise topographic localization. It has been showed to be useful in the evaluation of patients with cancer at diagnosis and staging, in monitoring the response to treatment and during follow up, for early detection of recurrence.
Fusion images of nuclear medicine and CT or MR have overcome the inherent limitations of both modalities, and valuable physiologic information was acquaired benefitting from a precise topographic localization. It has been showed to be useful in the evaluation of patients with cancer at diagnosis and staging, in monitoring the response to treatment and during follow up, for early detection of recurrence.
2003, 27(1): 17-20.
Abstract:
Fluorine-18 has predominant physical features with long half-life and the enough time for preparation of radiopharmaceuticals and PET imaging. Also, the chemical nature of fluorine-18 is similar to that of hydrogen, and the fluorine-18 labelled organic molecules can't change the non-labelled molecular character. Therefore, fluorine-18 is widely applied in the labelled glucose, amino acids, fatty acids, nucleotide, receptor-ligand and neurotransmitter molecular etc., with the propose of detecting the blood flow, metabolism, synthesis of the protein and the neurotransmitter function in brain by PET imaging. It is very important in the basic science and clinical research to understand and master the preparation of the fluorine-18 and its labelled compounds.
Fluorine-18 has predominant physical features with long half-life and the enough time for preparation of radiopharmaceuticals and PET imaging. Also, the chemical nature of fluorine-18 is similar to that of hydrogen, and the fluorine-18 labelled organic molecules can't change the non-labelled molecular character. Therefore, fluorine-18 is widely applied in the labelled glucose, amino acids, fatty acids, nucleotide, receptor-ligand and neurotransmitter molecular etc., with the propose of detecting the blood flow, metabolism, synthesis of the protein and the neurotransmitter function in brain by PET imaging. It is very important in the basic science and clinical research to understand and master the preparation of the fluorine-18 and its labelled compounds.
2003, 27(1): 21-24.
Abstract:
PET scanning in liver carcinoma has a definite clinical impact on identification of primary and metastatic tumor-especially on diagnosis, staging, and therapy of liver carcinoma. In addition, combined with CT, MRI, and ultrasound, PET can improve curative effect. Meanwhile, it is also important to curative effect of liver carcinoma.
PET scanning in liver carcinoma has a definite clinical impact on identification of primary and metastatic tumor-especially on diagnosis, staging, and therapy of liver carcinoma. In addition, combined with CT, MRI, and ultrasound, PET can improve curative effect. Meanwhile, it is also important to curative effect of liver carcinoma.
2003, 27(1): 25-27.
Abstract:
As the applications of metabolic imaging are expanding, radiolabeled amino acids has gained increased clinical interest. It is necessary to understand the basic aspects of amino acid metabolism and radiolabeled|and finally describe in the tumors. Have been most used clinically, such as, 11C-methionine, 11C-tyrosine and 123I-iodomethyltyrosine. And the theoretic and clinical back-ground of amino acid imaging is clear and is fit for clinical applications. Contrasting with the 18F-FDG PET suggested that is less troubled by interfering uptake in inflammatory tissues. There is a more accuracy in the brain tumors specially. In the other tumor types has been shown sufficiently.
As the applications of metabolic imaging are expanding, radiolabeled amino acids has gained increased clinical interest. It is necessary to understand the basic aspects of amino acid metabolism and radiolabeled|and finally describe in the tumors. Have been most used clinically, such as, 11C-methionine, 11C-tyrosine and 123I-iodomethyltyrosine. And the theoretic and clinical back-ground of amino acid imaging is clear and is fit for clinical applications. Contrasting with the 18F-FDG PET suggested that is less troubled by interfering uptake in inflammatory tissues. There is a more accuracy in the brain tumors specially. In the other tumor types has been shown sufficiently.
2003, 27(1): 28-30.
Abstract:
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan, which is the most severe accident since Chernobyl catastrophe. 213 people were exposed to radiation,among them 2 workers were exposed to 16~23Gy and 6~10Gy individually, one worker was 2Gy, 2 people was 10mSv and 208 person was 0~5mSv. I was invited to attend an international symposium on "The Criticality Accident in Tokaimura Medical Aspects of Radiation Emergency" in Chiba Japan on December 2000. An overview of the accident, dose estimation and neutron relative biological effects are discussed in this article.
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan, which is the most severe accident since Chernobyl catastrophe. 213 people were exposed to radiation,among them 2 workers were exposed to 16~23Gy and 6~10Gy individually, one worker was 2Gy, 2 people was 10mSv and 208 person was 0~5mSv. I was invited to attend an international symposium on "The Criticality Accident in Tokaimura Medical Aspects of Radiation Emergency" in Chiba Japan on December 2000. An overview of the accident, dose estimation and neutron relative biological effects are discussed in this article.
2003, 27(1): 31-34.
Abstract:
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan. An overview of the accident and dose estimation was discussed elsewhere. Here we discuss clinical management of pa-tiant A.
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan. An overview of the accident and dose estimation was discussed elsewhere. Here we discuss clinical management of pa-tiant A.
2003, 27(1): 35-37,41.
Abstract:
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan. An overview of the accident and dose estimation was discussed elsewhere. Here we discuss clinical management of patiant B and C.
A criticality accident occurred on September 30,1999 at the uranium processing plant in Tokaimura Japan. An overview of the accident and dose estimation was discussed elsewhere. Here we discuss clinical management of patiant B and C.
2003, 27(1): 38-41.
Abstract:
GM-CSF is the early discovered hematopoietic growth factor. Various kind of cells can synthesize and secreted GM-CSF by some stimulation. GM-CSF can stimulate the proliferation and differentiation of bone marrow hematopoietic progenitor cells and activate the proliferation and maturity of neutrophils, eosinophils, and macrophages. GM-CSF also stimulate growth of megakaryocyte and erythrocyte. Some change of GM-CSF level can be found after radiation in animal, which can accelerate the recovery of radiation injury.
GM-CSF is the early discovered hematopoietic growth factor. Various kind of cells can synthesize and secreted GM-CSF by some stimulation. GM-CSF can stimulate the proliferation and differentiation of bone marrow hematopoietic progenitor cells and activate the proliferation and maturity of neutrophils, eosinophils, and macrophages. GM-CSF also stimulate growth of megakaryocyte and erythrocyte. Some change of GM-CSF level can be found after radiation in animal, which can accelerate the recovery of radiation injury.
2003, 27(1): 42-44.
Abstract:
In the present experiment, recombinant human interleukin-11 (rhIL-11) significantly improved the proliferation activity of hematopoietic cells in the human bone marrow cell culture and increased the number of colonies of multilineage progenitor cells. Meylosuppressed mice or rhesus monkeys by chemo-or radiotherapy had higher platelet counts than those of controls after rhIL-11 treatment. rhIL-11 is safe and effective in reducing chemo-and/or radiotherapy associated thrombocytopenia and the need for platelet transfusions in patients who undergo intensive chemotherapy. rhIL-11 is likely to become an effective agent in correcting meylosuppression induced by radiation or chemotherapy
In the present experiment, recombinant human interleukin-11 (rhIL-11) significantly improved the proliferation activity of hematopoietic cells in the human bone marrow cell culture and increased the number of colonies of multilineage progenitor cells. Meylosuppressed mice or rhesus monkeys by chemo-or radiotherapy had higher platelet counts than those of controls after rhIL-11 treatment. rhIL-11 is safe and effective in reducing chemo-and/or radiotherapy associated thrombocytopenia and the need for platelet transfusions in patients who undergo intensive chemotherapy. rhIL-11 is likely to become an effective agent in correcting meylosuppression induced by radiation or chemotherapy
2003, 27(1): 45-47.
Abstract:
Two-dimensional polyacrylamide gel electrophoresis is the key separation technique in proteomics research, which is designed by protein character:molecular weight and PI. Some progress has been made in disease mechanism detection, tumour indicator research and drug development. This technique also has some potential application in radiation research.
Two-dimensional polyacrylamide gel electrophoresis is the key separation technique in proteomics research, which is designed by protein character:molecular weight and PI. Some progress has been made in disease mechanism detection, tumour indicator research and drug development. This technique also has some potential application in radiation research.
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