2002 Vol. 26, No. 5
Display Method:
2002, 26(5): 193-195.
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Abstract:
18F-AMT (18F-α-methyl-tyrosine)is a newly developed positron tumor positive imaging agent.In this review the synthesis method,biodistribution,in vitro study and clinical application result of 18F-AMT are discussed separately.
18F-AMT (18F-α-methyl-tyrosine)is a newly developed positron tumor positive imaging agent.In this review the synthesis method,biodistribution,in vitro study and clinical application result of 18F-AMT are discussed separately.
2002, 26(5): 196-199.
Abstract:
13C breath test has been widely used in research of nutrition,pharmacology and gastroenterology for its properties such as safety,noninvasion and so on.This review describes the principle,methodology of 13C breath test and its application in detection to Helicobacter pylori infect ion in stomach and small bowl bacterial overgrowth,measurement of gastric empt ying,pancreatic exocrine function and liver function with various substrates.
13C breath test has been widely used in research of nutrition,pharmacology and gastroenterology for its properties such as safety,noninvasion and so on.This review describes the principle,methodology of 13C breath test and its application in detection to Helicobacter pylori infect ion in stomach and small bowl bacterial overgrowth,measurement of gastric empt ying,pancreatic exocrine function and liver function with various substrates.
2002, 26(5): 200-204.
Abstract:
Situation of current study and clinic application of main imaging agents for infection and inflammation is summarized.These agents include radiolabelled small molecular compounds,leucocytes,large molecular proteins,liposomes,antibiotics,biotins and etc.
Situation of current study and clinic application of main imaging agents for infection and inflammation is summarized.These agents include radiolabelled small molecular compounds,leucocytes,large molecular proteins,liposomes,antibiotics,biotins and etc.
2002, 26(5): 205-209.
Abstract:
18FF-FDG imaging can provide information about the biologic characteristics of malignant cells,and has high target-to-nontarget ratios in most common neoplasms,recently has been successfully used in various neoplasms throughout the body.However 18F-FDG is a non specific tracer,and it has been found to accumulate at sites of normal tissue and some benign pathologic.This uptake of nonmalignant tissue may be misinterpreted as a false positive result or mask a nearby malignant lesion.We describe various nonmalignant uptake's characteristic and differential including physiologic,benign,infection and inflammation,image fusion,dual time point imaging be applied to distinguish nonmalignant accumulations.Con sider the combined imaging fusion is the first optimal modality in distinguish m alignant accumulations from physiologic.
18FF-FDG imaging can provide information about the biologic characteristics of malignant cells,and has high target-to-nontarget ratios in most common neoplasms,recently has been successfully used in various neoplasms throughout the body.However 18F-FDG is a non specific tracer,and it has been found to accumulate at sites of normal tissue and some benign pathologic.This uptake of nonmalignant tissue may be misinterpreted as a false positive result or mask a nearby malignant lesion.We describe various nonmalignant uptake's characteristic and differential including physiologic,benign,infection and inflammation,image fusion,dual time point imaging be applied to distinguish nonmalignant accumulations.Con sider the combined imaging fusion is the first optimal modality in distinguish m alignant accumulations from physiologic.
2002, 26(5): 210-212.
Abstract:
Technegas is a suspension of ultrafine 99Tcm labelled carbon particles produced in an atmosphere of high-quality argon. It is cheap,always available and easy to use,delivers a low radiation dose,and for the most parts,provides good quality lung images.In normal lungs,there was no difference radios in the lungs between Technegas and inhaled 81Krm、133Xe.Compared with ordinary radioaerosols,it causees fewer and less intense foci of parasitic bronchial activity,and assures good peripheral penetration and alveolar deposition.And Technegas ventilation imaging also has many ad-vantages over other methods,such as X-ray examinations and bronchoscopy.
Technegas is a suspension of ultrafine 99Tcm labelled carbon particles produced in an atmosphere of high-quality argon. It is cheap,always available and easy to use,delivers a low radiation dose,and for the most parts,provides good quality lung images.In normal lungs,there was no difference radios in the lungs between Technegas and inhaled 81Krm、133Xe.Compared with ordinary radioaerosols,it causees fewer and less intense foci of parasitic bronchial activity,and assures good peripheral penetration and alveolar deposition.And Technegas ventilation imaging also has many ad-vantages over other methods,such as X-ray examinations and bronchoscopy.
2002, 26(5): 213-216.
Abstract:
The study reviews the present situation of radioimmunoassay,enzyme immunoassay,luminescence im-munoassay,fluorescence immunoassays,and some recent new techniques,also evaluates the current status of labelling immunoassay.
The study reviews the present situation of radioimmunoassay,enzyme immunoassay,luminescence im-munoassay,fluorescence immunoassays,and some recent new techniques,also evaluates the current status of labelling immunoassay.
2002, 26(5): 216-219.
Abstract:
MIBG (metaiodobenzylguanidine)is a functional analog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.
MIBG (metaiodobenzylguanidine)is a functional analog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.
2002, 26(5): 220-222.
Abstract:
Octreotide can be labelled with 188Re by using the direct labelling approach and the bifunctional chelate approach.The direct labelling approach concludes pretinning procedure and two-step reduction method.By pretinning pro-cedure,both octreotide and perrhenate are reduced by SnCl2.Rhenium of a lower oxidation state is bound to octreotide directly.By two-step reduction method,octreotide and the perrhenate are reduced by different reduction agent respectively.The direct radiolabelling approaches allow very high radiochemical purity,high specific activity formulation,low radiocolloid formation and good in vitro stability,without the need for post-radiolabel ling purification to eliminate the un-bound free radioisotope.A kit could be developed which would merely require the mixing of perrhenate with the other reagents in a single vial.
Octreotide can be labelled with 188Re by using the direct labelling approach and the bifunctional chelate approach.The direct labelling approach concludes pretinning procedure and two-step reduction method.By pretinning pro-cedure,both octreotide and perrhenate are reduced by SnCl2.Rhenium of a lower oxidation state is bound to octreotide directly.By two-step reduction method,octreotide and the perrhenate are reduced by different reduction agent respectively.The direct radiolabelling approaches allow very high radiochemical purity,high specific activity formulation,low radiocolloid formation and good in vitro stability,without the need for post-radiolabel ling purification to eliminate the un-bound free radioisotope.A kit could be developed which would merely require the mixing of perrhenate with the other reagents in a single vial.
2002, 26(5): 222-224.
Abstract:
The concept of sentinel lymph node (SLN)holds that the lymphatic effluent of a tumor drains initially to one or two lymph nodes before other nodes receive the tumoral drainage.It is a great advance in breast cancer surgery to one or two lymph nodes before other nodes receive the tumoral drainage.It is a great advance in breast cancer surgery to predict regional nodal metastases by sentinel lymph node detection in breast cancer,which can give the more refinedstaging of breast cancer.According to the different tracers,there are two ways to detect SLN.Using a radiopharmaceutical to identify SLN in breast cancer is superior,and differs from traditional lymphoscintigraphy.Some factors could affect SLN detection in breast cancer,and many efforts should be taken to improve SLN detection techniques.
The concept of sentinel lymph node (SLN)holds that the lymphatic effluent of a tumor drains initially to one or two lymph nodes before other nodes receive the tumoral drainage.It is a great advance in breast cancer surgery to one or two lymph nodes before other nodes receive the tumoral drainage.It is a great advance in breast cancer surgery to predict regional nodal metastases by sentinel lymph node detection in breast cancer,which can give the more refinedstaging of breast cancer.According to the different tracers,there are two ways to detect SLN.Using a radiopharmaceutical to identify SLN in breast cancer is superior,and differs from traditional lymphoscintigraphy.Some factors could affect SLN detection in breast cancer,and many efforts should be taken to improve SLN detection techniques.
2002, 26(5): 225-227.
Abstract:
Radioimmunotherapy is a major component of radionuclide therapy and always being the main field of re-search.ZevalinTM is the first FDA marketing approved radioimmunotherapy agent which is indicated for the treatment of relapsed or refractory low grade non-Hodgkin's lymphoma.In this review,the component,therapeutic regimen,pharmacological mechanism,radiation dosage and clinical experiment result of ZevalinTM are described respectively.
Radioimmunotherapy is a major component of radionuclide therapy and always being the main field of re-search.ZevalinTM is the first FDA marketing approved radioimmunotherapy agent which is indicated for the treatment of relapsed or refractory low grade non-Hodgkin's lymphoma.In this review,the component,therapeutic regimen,pharmacological mechanism,radiation dosage and clinical experiment result of ZevalinTM are described respectively.
2002, 26(5): 227-230.
Abstract:
The therapy of tumor that permanent implantion with 125I seeds could supplied bigger radiation doses for fault tissue to suppress o r destroy tissue of tumor effectively.It is a simple and safety treatment.The 125I seeds implantation by guided method mostly is widely used treating prostate cancer abroad today.
The therapy of tumor that permanent implantion with 125I seeds could supplied bigger radiation doses for fault tissue to suppress o r destroy tissue of tumor effectively.It is a simple and safety treatment.The 125I seeds implantation by guided method mostly is widely used treating prostate cancer abroad today.
2002, 26(5): 231-236.
Abstract:
Positron emission tomography (PET)has been widely used to visualize,localize and quantify the different biochemical processes and parameters such as metabolic processes and receptor densities using anatomical modality.The development of PET technique is to depend on the development and application of positron emitting tracers.The PET radiotracers labelled with positron emitting radionuclides such as 18F,15O,13N and 11C are commonly produced in cyclotron.Therefore,it is very important to master the operational principles and the essential component of the cyclotron,and to select the suitable positron emitting radionuclides and corresponding la belling precursors for the routine production and development of PET imaging agents.This review described the principle of operation of the cyclotron,types of medical cyclotrons,production of radionuclides and labelling precursors.
Positron emission tomography (PET)has been widely used to visualize,localize and quantify the different biochemical processes and parameters such as metabolic processes and receptor densities using anatomical modality.The development of PET technique is to depend on the development and application of positron emitting tracers.The PET radiotracers labelled with positron emitting radionuclides such as 18F,15O,13N and 11C are commonly produced in cyclotron.Therefore,it is very important to master the operational principles and the essential component of the cyclotron,and to select the suitable positron emitting radionuclides and corresponding la belling precursors for the routine production and development of PET imaging agents.This review described the principle of operation of the cyclotron,types of medical cyclotrons,production of radionuclides and labelling precursors.
2002, 26(5): 237-239.
Abstract:
Radiochromic film dosimetry was developed to measure ionization irradiation dose for industry and medicine.At this time,there are no comprehensive guideline on the medical application,calibration method and densitometer system for medicine.The review gives update on Radiochromic film dosimetry used for medicine,including principles,film model and material,characteristics,calibration method,scanning densitometer system and medical application.
Radiochromic film dosimetry was developed to measure ionization irradiation dose for industry and medicine.At this time,there are no comprehensive guideline on the medical application,calibration method and densitometer system for medicine.The review gives update on Radiochromic film dosimetry used for medicine,including principles,film model and material,characteristics,calibration method,scanning densitometer system and medical application.
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