2002 Vol. 26, No. 2
Display Method:
2002, 26(2): 49-52.
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Abstract:
Positron emission tomography, as the leading technology providing molecular imaging of biological processes' is widely used on living laboratory animals. High-resolution dedicated animal PET scanners have been developed. Al though the dedicated animal PET faces obstacles and challenges, this advanced technology would play an important role in molecular biomedicine researches, such as diseases study, medicine development, and gene therapy.
Positron emission tomography, as the leading technology providing molecular imaging of biological processes' is widely used on living laboratory animals. High-resolution dedicated animal PET scanners have been developed. Al though the dedicated animal PET faces obstacles and challenges, this advanced technology would play an important role in molecular biomedicine researches, such as diseases study, medicine development, and gene therapy.
2002, 26(2): 53-56.
Abstract:
Dopamine D3 receptor ligands were reviewed in this paper. Aminotetralin derivatives is a main kind of them. After comparing the molecule structure, receptor affinity and receptor selectivity of them, I made a prospective research future of high selective and affinity ligands of dopamine D3 receptor.
Dopamine D3 receptor ligands were reviewed in this paper. Aminotetralin derivatives is a main kind of them. After comparing the molecule structure, receptor affinity and receptor selectivity of them, I made a prospective research future of high selective and affinity ligands of dopamine D3 receptor.
2002, 26(2): 57-60.
Abstract:
This study reviews the improvement and the clinical role of new and more sensitive methods for measure-ments of serum thyrotropin (TSH).It's very important that laboratories should independently establish and periodically check their methodological indices of sensitivity with which to evaluate different methods and to improve their correlation with clinical performance.
This study reviews the improvement and the clinical role of new and more sensitive methods for measure-ments of serum thyrotropin (TSH).It's very important that laboratories should independently establish and periodically check their methodological indices of sensitivity with which to evaluate different methods and to improve their correlation with clinical performance.
2002, 26(2): 60-63.
Abstract:
Recently the hormone leptin has been regarded as hormonal signal linking adipose tissue status with a number of key central nervous system circuits. The role of leptin and its feedback system in man is partly revealed. Hypothalamic centers appear to control appetite, metabolic rate and activity level in a coordinate manner. Within the hypothalamus, known weight regulatory molecules include leptin, neuropeptide Y and POMC. We integrated new information into a revised model for understanding this important regulatory process. Our model of energy homeostasis propose that the inter-action of leptin with various neuroendocrine pathway in the brain and in the periphery to affect food-take.
Recently the hormone leptin has been regarded as hormonal signal linking adipose tissue status with a number of key central nervous system circuits. The role of leptin and its feedback system in man is partly revealed. Hypothalamic centers appear to control appetite, metabolic rate and activity level in a coordinate manner. Within the hypothalamus, known weight regulatory molecules include leptin, neuropeptide Y and POMC. We integrated new information into a revised model for understanding this important regulatory process. Our model of energy homeostasis propose that the inter-action of leptin with various neuroendocrine pathway in the brain and in the periphery to affect food-take.
2002, 26(2): 64-67.
Abstract:
99Tcm-MIBI(99Tcm-sestamibi)scintigaphy has high sensitivity, specificity and accuracy in diagnosis of breast can-cer. It can also be used to detect axillary lymph node metastases. Furthermore, associated with other methods, 99Tcm-MIBI seintigraphy improve on the accuracy of detecting breast cancer.
99Tcm-MIBI(99Tcm-sestamibi)scintigaphy has high sensitivity, specificity and accuracy in diagnosis of breast can-cer. It can also be used to detect axillary lymph node metastases. Furthermore, associated with other methods, 99Tcm-MIBI seintigraphy improve on the accuracy of detecting breast cancer.
2002, 26(2): 67-71.
Abstract:
This article discussed the main mechanism of multidrug resistance of breast cancer tissues, and the correla-tion between technetium-99m sestamibi (99Tcm-MIBI) breast imaging results, with the expression of drug resistance pro-teins P-glycoprotein and glutathione-S-transfease-π in human breast cancer.Though not all the results reported before matched each other, as a kind of a noninvasive simple functional test imaging technology in vitro, SPECT can be used to diagnose P-glycoprotein expression in breast cancer, and can be used to predict chemotherapy response.
This article discussed the main mechanism of multidrug resistance of breast cancer tissues, and the correla-tion between technetium-99m sestamibi (99Tcm-MIBI) breast imaging results, with the expression of drug resistance pro-teins P-glycoprotein and glutathione-S-transfease-π in human breast cancer.Though not all the results reported before matched each other, as a kind of a noninvasive simple functional test imaging technology in vitro, SPECT can be used to diagnose P-glycoprotein expression in breast cancer, and can be used to predict chemotherapy response.
2002, 26(2): 76-79.
Abstract:
Egr-1(early growth response-1)gene is an important member of the "Immediate Early Growth" gene family,participating in multiple radiation biological effects of the irradiated cells.Studies have shown that after ionizing radia-tion,Egr-1 gene can be activated at an early stage in many types of tumor and normal cells.Its actitivation and the conse-quent expression is believed to have a close relation to the change in cell growth,cell cycle and apoptosis of the irradiat-ed cells. Additionally,the radiation-inducible property of the Egr-1 gene regulating sequence confers potential clinical and genetic engineering uses.
Egr-1(early growth response-1)gene is an important member of the "Immediate Early Growth" gene family,participating in multiple radiation biological effects of the irradiated cells.Studies have shown that after ionizing radia-tion,Egr-1 gene can be activated at an early stage in many types of tumor and normal cells.Its actitivation and the conse-quent expression is believed to have a close relation to the change in cell growth,cell cycle and apoptosis of the irradiat-ed cells. Additionally,the radiation-inducible property of the Egr-1 gene regulating sequence confers potential clinical and genetic engineering uses.
2002, 26(2): 79-83.
Abstract:
p53,acting as a tumour suppressor gene,regulates the system of cell cycle and apoptosis when cells confront a variety of stress including DNA damage responding to ionizing radiation,nucleotide depletion,hypoxia or oncogene activation. In this article,the role and targets of p53 during cell cycle and apoptosis are reviewed. On the basis of it,we question factors of the decision to undergo growth arrest versus apoptosis in response to p53 expression.
p53,acting as a tumour suppressor gene,regulates the system of cell cycle and apoptosis when cells confront a variety of stress including DNA damage responding to ionizing radiation,nucleotide depletion,hypoxia or oncogene activation. In this article,the role and targets of p53 during cell cycle and apoptosis are reviewed. On the basis of it,we question factors of the decision to undergo growth arrest versus apoptosis in response to p53 expression.
2002, 26(2): 83-86.
Abstract:
The micronucleus assay is widely used both in genetic toxicology and in the radiation biomonitoring of human population. With the development of molecular genetics and fluorescence in situ hybridization (FISH), more have been known about micronucle. FISH can be used to interpret the formation mechanism, the function and the ultrastructure of the micronucleus, as well as the genetic evaluation of radiation damage.
The micronucleus assay is widely used both in genetic toxicology and in the radiation biomonitoring of human population. With the development of molecular genetics and fluorescence in situ hybridization (FISH), more have been known about micronucle. FISH can be used to interpret the formation mechanism, the function and the ultrastructure of the micronucleus, as well as the genetic evaluation of radiation damage.
2002, 26(2): 87-89.
Abstract:
Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei which have high energy and shortrange. BNCT is a binary approach:a boron-labeled compound is administered that delivered high concentration of 10B of the target tumor relative to the surrounding tissues. The therapeutic efficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells. The development of BNCT, characteristic of radiation fields and calculations of energy deposition are described in this paper.
Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei which have high energy and shortrange. BNCT is a binary approach:a boron-labeled compound is administered that delivered high concentration of 10B of the target tumor relative to the surrounding tissues. The therapeutic efficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells. The development of BNCT, characteristic of radiation fields and calculations of energy deposition are described in this paper.
2002, 26(2): 90-92.
Abstract:
As a retrospective dosimetry technique, electron spin resonance has been applied to dose reconstruction wider and wider. Principle and outline of the ESR tooth enamel dose assessment are described, includ the collection and preparation of samples, the measurement and signal processing, dose calibration of ESR response interpretation of results, souces of error and the latest achivement. In addition, some examples of dose reconstruction by ESR using tooth enamel are given.
As a retrospective dosimetry technique, electron spin resonance has been applied to dose reconstruction wider and wider. Principle and outline of the ESR tooth enamel dose assessment are described, includ the collection and preparation of samples, the measurement and signal processing, dose calibration of ESR response interpretation of results, souces of error and the latest achivement. In addition, some examples of dose reconstruction by ESR using tooth enamel are given.
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