2001 Vol. 25, No. 5
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2001, 25(5): 193-198.
[PDF 261KB]
Abstract:
Leptin is a hormone synthesized and secreted by lipid cells.It is a product encoded and expressed by the obese gene. Administration of recombinant leptin decreases food intake,increases energy expenditure and promotes weight loss. Most studies indicate that leptin is a main regulating factor of catabolism and anabolism of adipose tissue. The circulating leptin level is a sensitive index which indicates the confusion of the rate of lipid metabolism such as hyperlipemia, lipoliver and so on.The human leptin radioimmunoassay has been developed to quantitate human leptin in plasma or serum, and to further investigate the relationship between serum leptin concentration and body fat, gender,age,sexual hormones, endocrine of insulin, etc. Especially, serum leptin concentrations are correlated with body-mass-index (BMI),suggesting that most obese persons are resistant to leptin; Those who are relatively deficient of leptin may become the good candidates of leptin treatment in the future.The discovery and application of leptin make the study of obesity,non-insulin dependent diabetes and other correlation diseases enter a new stage.
Leptin is a hormone synthesized and secreted by lipid cells.It is a product encoded and expressed by the obese gene. Administration of recombinant leptin decreases food intake,increases energy expenditure and promotes weight loss. Most studies indicate that leptin is a main regulating factor of catabolism and anabolism of adipose tissue. The circulating leptin level is a sensitive index which indicates the confusion of the rate of lipid metabolism such as hyperlipemia, lipoliver and so on.The human leptin radioimmunoassay has been developed to quantitate human leptin in plasma or serum, and to further investigate the relationship between serum leptin concentration and body fat, gender,age,sexual hormones, endocrine of insulin, etc. Especially, serum leptin concentrations are correlated with body-mass-index (BMI),suggesting that most obese persons are resistant to leptin; Those who are relatively deficient of leptin may become the good candidates of leptin treatment in the future.The discovery and application of leptin make the study of obesity,non-insulin dependent diabetes and other correlation diseases enter a new stage.
2001, 25(5): 198-203.
Abstract:
Stress myocardial perfusion imaging and stress echocardiography are both noninvasive diagnostic techniques. Both techniques are very valuable for assessment of diagnosis and risk stratification of patients with coronary artery disease, while both have their advantages and disadvantages. The overall sensitivity for diagnosis of coronary artery disease is higher by stress myocardial perfusion imaging than by stress echocardiography, whereas the specificity is slightly higher by the later.With regard to risk stratification of patients with coronary artery disease, stress myocardial perfusion imaging is more valuable than stress echocardiography. A normal stress myocardial perfusion imaging result indicates an exceedingly low risk even in patients with angiographic coronary artery disease.
Stress myocardial perfusion imaging and stress echocardiography are both noninvasive diagnostic techniques. Both techniques are very valuable for assessment of diagnosis and risk stratification of patients with coronary artery disease, while both have their advantages and disadvantages. The overall sensitivity for diagnosis of coronary artery disease is higher by stress myocardial perfusion imaging than by stress echocardiography, whereas the specificity is slightly higher by the later.With regard to risk stratification of patients with coronary artery disease, stress myocardial perfusion imaging is more valuable than stress echocardiography. A normal stress myocardial perfusion imaging result indicates an exceedingly low risk even in patients with angiographic coronary artery disease.
2001, 25(5): 204-209.
Abstract:
Na+/I- symporter is a membrane glycoprotein that catalyzes the active accumulation of I-. The abnormality of NIS gene will lead to thyroid disease. We had succeeded in transfecting the Na+/I- symporter into tumors for radioiodide concentration. However, the effective half life is too short to acquire therapeutic dose. So we should research into prolonging the effective half-life and increased effective transfection.
Na+/I- symporter is a membrane glycoprotein that catalyzes the active accumulation of I-. The abnormality of NIS gene will lead to thyroid disease. We had succeeded in transfecting the Na+/I- symporter into tumors for radioiodide concentration. However, the effective half life is too short to acquire therapeutic dose. So we should research into prolonging the effective half-life and increased effective transfection.
2001, 25(5): 209-212.
Abstract:
Dementing illnesses comprise Alzheimer's disease (AD), Pick's disease, Multi-infarct dementia (MID) and other neurological disorders. These diseases have different clinical characters respectively. Neuropsychological examinations can help to diagnose and differential diagnose dementias. The development of neuroimaging dementias is more and more rapid. 18F-FDG PET method shows neocortical hypometabolism occurring in the biparietotemporal lobes and left-right asymmetry of AD patients in the early stage . It can also differential diagnose AD from other dementias.
Dementing illnesses comprise Alzheimer's disease (AD), Pick's disease, Multi-infarct dementia (MID) and other neurological disorders. These diseases have different clinical characters respectively. Neuropsychological examinations can help to diagnose and differential diagnose dementias. The development of neuroimaging dementias is more and more rapid. 18F-FDG PET method shows neocortical hypometabolism occurring in the biparietotemporal lobes and left-right asymmetry of AD patients in the early stage . It can also differential diagnose AD from other dementias.
2001, 25(5): 213-216.
Abstract:
Radiolabeled antisense imaging may be defined as the detection of diseases through the administration of radiolabeled antisense oligonucleotide designed to bind in a sequence-specific manner to the machinery of translation or transcription. No immunogenity, low molecular weight of probes and easily penetrating the tumor cells are some of it's good aspects.Despite its good prospective, factors as selection of targeted serial, identification of ideal oligonucleotides are still roadblocks in developing antisense imaging. Many problems must be solved before in vivo application of antisense imaging, among those including in vivo stability, specific absorption and retention by targeted cells, nonspecific serum binding, and so on.
Radiolabeled antisense imaging may be defined as the detection of diseases through the administration of radiolabeled antisense oligonucleotide designed to bind in a sequence-specific manner to the machinery of translation or transcription. No immunogenity, low molecular weight of probes and easily penetrating the tumor cells are some of it's good aspects.Despite its good prospective, factors as selection of targeted serial, identification of ideal oligonucleotides are still roadblocks in developing antisense imaging. Many problems must be solved before in vivo application of antisense imaging, among those including in vivo stability, specific absorption and retention by targeted cells, nonspecific serum binding, and so on.
2001, 25(5): 221-224.
Abstract:
In the present paper we briefly reviewed the effects of ionizing radiation on central nervous system (CNS), including the effects of ionizing radiation on the developmental CNS,neurons, neural stem cells and gliocytes, the radioreponses of CNS injury and so on.
In the present paper we briefly reviewed the effects of ionizing radiation on central nervous system (CNS), including the effects of ionizing radiation on the developmental CNS,neurons, neural stem cells and gliocytes, the radioreponses of CNS injury and so on.
2001, 25(5): 225-228.
Abstract:
Radiation can cause a lot of biological effects in irradiated cells, such as mutations,changes of gene expression, cell growth and so on. But these effects can also be observed in non-irradiated cells. This phenomenon is termed as bystander effect. Up to now, the mechanisms of bystander effects have been known very little. It is believed that extracellular factors or intercellular communications play a very important role in the process.
Radiation can cause a lot of biological effects in irradiated cells, such as mutations,changes of gene expression, cell growth and so on. But these effects can also be observed in non-irradiated cells. This phenomenon is termed as bystander effect. Up to now, the mechanisms of bystander effects have been known very little. It is believed that extracellular factors or intercellular communications play a very important role in the process.
2001, 25(5): 228-232.
Abstract:
Radiotherapy is a promising technique to substantianlly reduce the post-PTCA. restenosis Many study work has been done in recent years. These work are mainly focused on the mechanism of inhibiting restenosis by radiation: the time,dose, dose rate, the form and the side effects of radiotherapy.
Radiotherapy is a promising technique to substantianlly reduce the post-PTCA. restenosis Many study work has been done in recent years. These work are mainly focused on the mechanism of inhibiting restenosis by radiation: the time,dose, dose rate, the form and the side effects of radiotherapy.
2001, 25(5): 233-236.
Abstract:
It briefly describes the current states and operative procedure of interstitial implantation brachytherapy treatment of prostate carcinoma. The characteristics and selection of employed radioisotopes are introduced.It also evaluates the indications,results and complications of this technique,and compar with the other therapies.
It briefly describes the current states and operative procedure of interstitial implantation brachytherapy treatment of prostate carcinoma. The characteristics and selection of employed radioisotopes are introduced.It also evaluates the indications,results and complications of this technique,and compar with the other therapies.
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