2001 Vol. 25, No. 1
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2001, 25(1): 1-3.
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Abstract:
Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation 3H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.
Ischemic preconditioning is the intrinsic and most potently myocardial protection we know now. To illu-minate its mechanism is the foundation of rational theraputic application. Nowadays there are some theories about delayed phase of preconditioning such as nitric oxide hypothesis, free radical mechanisms, protective protein syn-thesis and opening of AT P-sensitive potassium channels. By incorporation 3H-leucine, using liquid scintillation counter, we now know there was protective protein synthesis during preconditioning. SPECT could study the char-acteristics of preconditioned myocardium in vivo, and PET might further show the metabolism, energy consumption and its relationship to myocardium dysfunction.
2001, 25(1): 3-7.
Abstract:
Radionuclide imaging is helpfulin the early diagnosis of ulcerative colitis and Crohn's disease, especially it can provide us the disease activity and evaluate their responses to therapy. Several radiopharmaceuticals for the diagnosis of these two diseases have been reviewed. Meanwhile their advantages and disadvantages have been dis-cussed.
Radionuclide imaging is helpfulin the early diagnosis of ulcerative colitis and Crohn's disease, especially it can provide us the disease activity and evaluate their responses to therapy. Several radiopharmaceuticals for the diagnosis of these two diseases have been reviewed. Meanwhile their advantages and disadvantages have been dis-cussed.
2001, 25(1): 7-9.
Abstract:
Previous studies have shown that positron emission tomography (PET) can measure the biochemistry and physiologic function change in pituitary, including blood flow, perfusion, glucose metabolism, protein metabolism, receptor density. This article reviews recently research of PET imaging in pituitary adenomas. It re-flects the diagnosis, therapy management and prognosis of pituitary adenomas can be demonstrated by PET with different positron tracers. Therefore, PET imaging can lead to the improvement in research of pituitary adenomas and neurology.
Previous studies have shown that positron emission tomography (PET) can measure the biochemistry and physiologic function change in pituitary, including blood flow, perfusion, glucose metabolism, protein metabolism, receptor density. This article reviews recently research of PET imaging in pituitary adenomas. It re-flects the diagnosis, therapy management and prognosis of pituitary adenomas can be demonstrated by PET with different positron tracers. Therefore, PET imaging can lead to the improvement in research of pituitary adenomas and neurology.
2001, 25(1): 10-12.
Abstract:
As a medlod of fundional imaging,18F-FDG PET provides a measure of the biochemical varieties as well as the metabolic status of the tissues, which condbute to the accmate staging, assessment of malignancy, curative-effect and prognosis of lymphoma
As a medlod of fundional imaging,18F-FDG PET provides a measure of the biochemical varieties as well as the metabolic status of the tissues, which condbute to the accmate staging, assessment of malignancy, curative-effect and prognosis of lymphoma
2001, 25(1): 12-15.
Abstract:
99Tcm-tetrofosmin as a positive indicator in oncology,99Tcm-tetrofosmin scintigraphy has high sensitivity,specificity and accuracy in diagnosis of primary breast cancer, of local recurrence and of axillary lymph node metastases.99Tcm-tetrofosmin can also be used to detect bone metastases and recurrence after surgery. Furthermore,99Tcm-tetrofosmin presents promising perspectives in sentinel lymph node detection and imaging, in function imag-ing of P-glycoprotein and in guiding a biopsy. Associated with other methods,99Tcm-tetrofosmin scintigraphy improves the accuracy of detecting breast cancer.
99Tcm-tetrofosmin as a positive indicator in oncology,99Tcm-tetrofosmin scintigraphy has high sensitivity,specificity and accuracy in diagnosis of primary breast cancer, of local recurrence and of axillary lymph node metastases.99Tcm-tetrofosmin can also be used to detect bone metastases and recurrence after surgery. Furthermore,99Tcm-tetrofosmin presents promising perspectives in sentinel lymph node detection and imaging, in function imag-ing of P-glycoprotein and in guiding a biopsy. Associated with other methods,99Tcm-tetrofosmin scintigraphy improves the accuracy of detecting breast cancer.
2001, 25(1): 16-18.
Abstract:
Radionuclide scrotal scintigraphy is a noninvasive method in detecting varicocele. Up to now this method has been developed from qualitativeness, semi-quantitativeness to quantitativeness. It can give help to diagnosis,grade varicocele and prognosticate the effect of varicocelectomy.
Radionuclide scrotal scintigraphy is a noninvasive method in detecting varicocele. Up to now this method has been developed from qualitativeness, semi-quantitativeness to quantitativeness. It can give help to diagnosis,grade varicocele and prognosticate the effect of varicocelectomy.
2001, 25(1): 23-26,41.
Abstract:
Thc 125I with special biological and physical characters is available to interstitial brachytherapy. The 125I seeds implantation is widely used in treating malignant tumor abroad. Implantation with 125I seeds is an important and effective method in the treatment of prostate cancer, but it is performed as pilot study in the treatment of other tumors.
Thc 125I with special biological and physical characters is available to interstitial brachytherapy. The 125I seeds implantation is widely used in treating malignant tumor abroad. Implantation with 125I seeds is an important and effective method in the treatment of prostate cancer, but it is performed as pilot study in the treatment of other tumors.
2001, 25(1): 27-30.
Abstract:
Endovascular radiation is a promising technique to substantianlly reduce the restenosis post-PTCA. Inhi-bition of VSMCs by radiation is thought as the main cause, but the machanism of this is not clear. Inhibition of VSMCs proliferation and miagration by radiation is ragarded as the most important factor. The role of apoptosis in this couse is not determined. However, inhibition of macrophage and cytokines by radiation is emphasized recently.
Endovascular radiation is a promising technique to substantianlly reduce the restenosis post-PTCA. Inhi-bition of VSMCs by radiation is thought as the main cause, but the machanism of this is not clear. Inhibition of VSMCs proliferation and miagration by radiation is ragarded as the most important factor. The role of apoptosis in this couse is not determined. However, inhibition of macrophage and cytokines by radiation is emphasized recently.
2001, 25(1): 31-33.
Abstract:
There is an "edge effect" or "candy wrapper" problem at the stent edges for β-particle emitting stent im-plantation. The mechanism for "candy wrapper" may conclude low activity level of radiation, aggressive injury to vessel at the margins of the stent and neointimal proliferation due to low-dose radiation stimulation. The methods to solve the "candy wraper" could be proposed:(1) the square-shouldered balloon, (2) the cold-end stent, (3) the hot-end stent, (4) a self-expanding radioactive stent, (5) theγ-stent and so on.
There is an "edge effect" or "candy wrapper" problem at the stent edges for β-particle emitting stent im-plantation. The mechanism for "candy wrapper" may conclude low activity level of radiation, aggressive injury to vessel at the margins of the stent and neointimal proliferation due to low-dose radiation stimulation. The methods to solve the "candy wraper" could be proposed:(1) the square-shouldered balloon, (2) the cold-end stent, (3) the hot-end stent, (4) a self-expanding radioactive stent, (5) theγ-stent and so on.
2001, 25(1): 33-37.
Abstract:
The treatment of vessel restenosis by endovascular radiation is being taken into account. However, the mechanism for prevention of restenosis is not clear. Restenosis is a complex process that comprises endothelial cells and others. It appears, fundamentally, to be a wound-healing process. The injury of vascular endothelium is initial influence on the development ofrestenosis. The proliferation and apoptosis of endothelial cells will effect and intervene in the course of restenosis. Ionizing radiation will influence survival, apoptosis, proliferation, phenotype and function for endothelial cells. It will contribute the prevention of restenosis by means of the study of the effect of ionizing radiation on vascular endothelial cells.
The treatment of vessel restenosis by endovascular radiation is being taken into account. However, the mechanism for prevention of restenosis is not clear. Restenosis is a complex process that comprises endothelial cells and others. It appears, fundamentally, to be a wound-healing process. The injury of vascular endothelium is initial influence on the development ofrestenosis. The proliferation and apoptosis of endothelial cells will effect and intervene in the course of restenosis. Ionizing radiation will influence survival, apoptosis, proliferation, phenotype and function for endothelial cells. It will contribute the prevention of restenosis by means of the study of the effect of ionizing radiation on vascular endothelial cells.
2001, 25(1): 38-41.
Abstract:
Restenosis after vascular intervention influences the long-term curative effect seriously. Among the ther-apies for the reduction of restenosis, the endovascular radiation with radioistopes is a promising new avenue. At present, the relative device, dose and the attendant complications have been gradually recognized. Anyway, it is still a practicable way.
Restenosis after vascular intervention influences the long-term curative effect seriously. Among the ther-apies for the reduction of restenosis, the endovascular radiation with radioistopes is a promising new avenue. At present, the relative device, dose and the attendant complications have been gradually recognized. Anyway, it is still a practicable way.
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