Latest Accepted
Display Method:
, Available online , doi: 10.3760/cma.j.cn121381-202305018-00400
[PDF 2051KB]
Abstract:
Objective To investigate the value of 18F-FDG PET/CT metabolic parameters combined with serum CEA、CA19-9、CA72-4 in predicting microsatellite instability (MSI)state in patients with colorectal cancer(CRC). Methods The clinicl data of 96 patients [62 males,34 females, aged (60.06±13.80 years)] who received PET/CT examination and pathologically confirmed as colorectal cancer in the First Affiliated Hospital of Zhengzhou University from June 2018 to August 2022 were retrospectively analyzed. The patients were divided into MSI group and microsatellite stability (MSS) group according to the results of immunohistochemistry. Maximum standardized uptake value (SUVmax) and peak standardized uptake value (SUVpeak) of region of in inrerest (ROI) were measured, and the standardized uptake value of ROI was 2.5 and 40% of SUVmax as thresholds, respectively, to obtain SUVmean, tumor metabolic volume (MTV) and total lesion glycolysis (TLG). Two independent sample Student's t, χ2test and Mann-Whitney U test were used to compare the differences of each parameter between MSI group and MSS group. Multivariate logistic regression was used to analyze the independent predictor of MSI. ROC curve was used to analyze its predictive efficacy. Results A tatol of 96 patients,78 (81.25%) were MSI state and 18 (18.75%) were MSS state. There were significant differences of in tumor primary location, differentiation degree and serum levels of CEA, CA19-9 and CA72-4 between MSS group and MSI group (χ2=4.287~5.103, Z=−3.467~2.412, all P<0.05). In addition, there was no significant difference in sex, age, tumor length along intestinal axis, histological type, gross type, regional lymph node metastasis, TNM stage, vascular invasion, nerve invasion and margin invasion between the two groups (t=0.626, χ2=0~3.108, all P>0.05). There was no significant difference in SUVmax, SUVpeak and SUVmean, MTV and TLG with SUV=2.5 as the threshold (Z−1.685~−0.122, all P>0.05). The MTV (Z=−2.351, P=0.019) and TLG (Z=−2.104, P=0.035) of the lesions with 40% of SUVmax as the threshold were significantly higher in MSI group than in MSS group, and the difference was statistically significant. Multivariate logistic regression analysis showed that CA72-4 (OR=1.147, 95%CI: 1.048~1.255, P=0.003), MTV40% (OR=1.092, 95%CI: 1.004~1.187, P=0.041)and TLG40% (OR=0.568, 95%CI: 0.345~0.936, P=0.026) was the independent predictor of MSI state in colorectal cancer patients. The AUC of MSI status of colorectal cancer measured by serum CA72-4 combined with MTV40% were 0.79 (95%CI: 0.643~0.926, P<0.001), sensitivity was 72%, specificity was 87%; when CA72-4 combined with TLG-40% predicted MSI status, AUC was 0.81 (95%CI: 0.676~0.933, P<0.001), sensitivity was 67%, specificity was 92%. Conclusions MTV40%, TLG40% and serum CA72-4 can predict MSI state in colorectal cancer. Using 18F-FDG PET/CT metabolic parameters combined with serum tumor markers to evaluate the status of MSI in patients with colorectal cancer can achieve non-invasive evaluation of MSI, so as to better guide the immunotherapy of CRC patients.
, Available online , doi: 10.3760/cma.j.cn121381-202403013-00401
Abstract:
Objective To investigate the variations in plaque distribution among individuals with mild carotid artery stenosis, with a focus on gender and age, utilizing data from the Chinese Atherosclerosis Risk Assessment phase Ⅱ (CARE-Ⅱ) study and carotid atherosclerotic plaque magnetic resonance imaging. This research seeks to provide the basis for implementing stratified management strategies for this specific patient population. Methods Data from 627 patients [399 males and 228 females, aged (60.92±9.96) years]with carotid artery stenosis < 50% in the CARE-Ⅱ study from January 2012 to December 2014 were analyzed. The patients were stratified into two cohorts based on gender. Following the protocols outlined in the North American Symptomatic Carotid Endarterectomy Trial (NASCET), various metrics including mean wall thickness, mean wall area, mean standardized wall index, wall volume, wall volume percentage, and degree of stenosis of the carotid artery were computed, alongside an assessment of the pathological features of plaque. The patients were categorized based on age (≤55 years and >55 years), and an analysis was conducted to examine gender disparities in carotid plaque characteristics. Logistic regression analysis was conducted to examine the associations between clinical and imaging factors and the presence of mild carotid artery vulnerable plaque. Results The results of the study indicate that in the male group, body mass index (t=−2.896, P=0.004), diastolic blood pressure (t=−4.163, P<0.001), and the proportion of smoking (χ2=222.008, P<0.001) were significantly higher compared to the female group. Conversely, age (t=3.098, P=0.002), total cholesterol (t=4.720, P<0.001), and low density lipoprotein (t=4.152, P<0.001) were significantly higher in the male group compared to the female group. Additionally, levels of high density lipoprotein (t=4.152, P< 0.001) were lower in the male group compared to the female group. The results indicate that male patients (Z=−6.009,9.217, 8.847, P<0.001) exhibited significantly higher average wall thickness [1.10(0.96,1.26)(mm)vs. 1.00(0.88, 1.13)(mm)] , average wall area [32.82(27.08, 37.62) (mm2)vs. 26.66(22.38, 31.46) (mm2)], and wall volume [1024.72(834.96, 1184.12) (mm3)vs. 831.64(705.22, 959.57) (mm3)] in the carotid artery compared to female patients. Additionally, the presence of lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH), and thin fibrous cap was more prevalent in individuals over the age of 55. Furthermore, multivariate logistic regression analysis identified age, degree of stenosis, and plaque burden as independent risk factors for AHA Type Ⅵ plaque formation. Conclusions The present study found that male and advanced age were associated with larger and more vulnerable carotid plaques in the Chinese population with mild carotid stenosis. Furthermore, age, plaque burden, and the severity of stenosis exhibit independent associations with the presence of vulnerable carotid plaques in cases of mild stenosis.For men over 55 years old with mild carotid stenosis, close follow-up is needed to evaluate the stability of their plaques.
, Available online , doi: 10.3760/cma.j.cn121381-202308029-00399
Abstract:
Lymphoma is a malignant tumor of the immune system originating from lymph nodes and lymphoid tissues. It is characterized by insidious onset and strong invasion, and is one of the tumors with the fastest growing incidence rate in China. At present, PET/CT has been an important imaging technique for the initial staging, re-staging, early treatment response, efficacy evaluation, prognosis prediction, and follow-up of malignant lymphoma. Due to the heterogeneity of lymphoma, such as different types of lymphoma in invasiveness, tissue origins, immune phenotypes, the stage of disease, and treatment response of different populations, non-18F-FDG PET imaging technologies are expected to show advantages over 18F-FDG PET/CT in the targeted diagnosis and treatment of some specific types of lymphoma. We focused on the research progress of non-18F-FDG PET molecular imaging in lymphoma, comparing the similarities and differences, advantages and disadvantages, application characteristics and development potentials between non-18F-FDG imaging agents and traditional imaging agent 18F-FDG, so as to provide new ideas and methods for the specific targeted diagnosis and treatment and personalized precision medicine of lymphoma.
Lymphoma is a malignant tumor of the immune system originating from lymph nodes and lymphoid tissues. It is characterized by insidious onset and strong invasion, and is one of the tumors with the fastest growing incidence rate in China. At present, PET/CT has been an important imaging technique for the initial staging, re-staging, early treatment response, efficacy evaluation, prognosis prediction, and follow-up of malignant lymphoma. Due to the heterogeneity of lymphoma, such as different types of lymphoma in invasiveness, tissue origins, immune phenotypes, the stage of disease, and treatment response of different populations, non-18F-FDG PET imaging technologies are expected to show advantages over 18F-FDG PET/CT in the targeted diagnosis and treatment of some specific types of lymphoma. We focused on the research progress of non-18F-FDG PET molecular imaging in lymphoma, comparing the similarities and differences, advantages and disadvantages, application characteristics and development potentials between non-18F-FDG imaging agents and traditional imaging agent 18F-FDG, so as to provide new ideas and methods for the specific targeted diagnosis and treatment and personalized precision medicine of lymphoma.
, Available online , doi: 10.3760/cma.j.cn121381-202306024-00398
Abstract:
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent tumor that most commonly occurs in the gastric mucosa. The authors presents a patient with gastric MALT lymphoma who underwent imaging with 18F-fluorodeoxyglucose(FDG) PET/CT and 68Ga-Pentixafor PET/CT. By analyzing and comparing clinical symptoms, conventional imaging findings, and 18F-FDG and 68Ga-Pentixafor PET/CT images, it deepens the understanding of gastric MALT lymphoma imaging with 68Ga-Pentixafor among clinical physicians.
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent tumor that most commonly occurs in the gastric mucosa. The authors presents a patient with gastric MALT lymphoma who underwent imaging with 18F-fluorodeoxyglucose(FDG) PET/CT and 68Ga-Pentixafor PET/CT. By analyzing and comparing clinical symptoms, conventional imaging findings, and 18F-FDG and 68Ga-Pentixafor PET/CT images, it deepens the understanding of gastric MALT lymphoma imaging with 68Ga-Pentixafor among clinical physicians.
Submit
Author Login
Referees
Editor-in-Chief
Editor Center
Email alert
RSS
