Volume 31 Issue 1
Feb.  2007
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The current status of the microdosimetry study of boron neutron capture therapy

  • Microdosimetry plays an important role in the clinical application of boron neutron capture therapy (BNCT). There is increasing interest to develop a set of microdosimetry model, which can exactly describe the nonuniformly distribution of dose at cellar or sub-cellar level as well as conveniently used in clinic. In this paper, will give emphasis to the introduction of some common methods of microdosimtry and some affective factors reported in current reseaches on BNCT.
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  • [1] Tooru K, Yoshinori S, Masayori I. A noninvasive dose estimation system for clinical BNCT based on PG-SPECT-conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors. Med Phys, 2000, 27(9):2124-2131.
    [2] 田源,张良安.放射免疫治疗中的核素微剂量研究.国际放射医学核医学杂志,2006,30(1):39-41.
    [3] Tung CJ, Liu CS, Wang JP, et al. Calculation of cellar microdosimetry parameter for alpha particles and electrons. Appl Radiat Isot, 2004, 61(5):739-743.
    [4] Rassow J, Sauerwein W, Wittig A, et al. Advantage and limitations of weighting factors and weighted dose quantities and their units in boron neutron capture therapy. Med Phys, 2004, 31(5):1128-1134.
    [5] Nievaart VA, Moss RL, Kloosterman JL, et al. A parameter study to determine the optimal source neutron energy in boron neutron capture therapy of brain tumours. Phys Med Biol, 2004, 49(18):4277-4292.
    [6] Santa Cruz GA, Zamenhof RG. The microdosimetry of the (10)B reaction in boron neutron capture therapy:a new generalized theory. Radiat Res, 2004, 162(6):702-710.
    [7] Kalend AM, Bloomer WD, Epperly MW. Dosimetric consequences of 10B (n, α)7Li reaction occurring at the celluar membrane.Int J Radiat Oncol Biol Phys, 1995, 31(1):171-178.
    [8] Kobayashi T, Kanda K. Analytical calculation of boron-10 dosage in cell nucleus for boron neutron capture therapy. Radiat Res, 1982,91(2):77-94.
    [9] Nichols TL, Miller LF, Kabalka GW. The microdosimetry of boron neutron capture therapy in a randomised ellipsoidal cell geometry.Radiat Prot Dosimetry, 2005, 116(2):466-469.
    [10] Gabel D, Foster S, Fairchild RG. The monte carlo simulation of the biological effect of the 10B (n,α)7Li reaction in ceils and tissues and its implication for boron neutron capture therapy. Radiat Res,1987, 111(1):14-25.
    [11] van Vliet-Vroegindeweij C, Wheeler F, Stecher-Rasmussen F, et al.Microdosimetry model for boron neutron capture therapy:Ⅰ. Determination of microscopic quantities of heavy particles on a cellular scale. Radiat Res, 2000, 155(3):490-497.
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The current status of the microdosimetry study of boron neutron capture therapy

    Corresponding author: ZHANG Liang-an, zhangla43@yahoo.com.cn
  • Department of Healthy Physics, Institute of Radiation Medicine, Chinese Academy of Medical Sicences and Peking Union Medical College, Tianjin 300192, China

Abstract: Microdosimetry plays an important role in the clinical application of boron neutron capture therapy (BNCT). There is increasing interest to develop a set of microdosimetry model, which can exactly describe the nonuniformly distribution of dose at cellar or sub-cellar level as well as conveniently used in clinic. In this paper, will give emphasis to the introduction of some common methods of microdosimtry and some affective factors reported in current reseaches on BNCT.

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