SPECT脑血流及介入显像在痴呆诊断中的临床应用进展

张凯军

Brain perfusion SPECT is a functional and noninvasive neuroimaging technique that allow the investigation of physiological and physiopathological events in the human brain,including cerebral perfusion and function.Interventional rCBF imaging can also evaluate cerebrovascular reserve.In clinically,rCBF imaging play an important role in the diagnosis and differential diagnosis of dementias,especially vascular and Alzheimer's dementia.If etiology of some types of dementias is determined so that it can be early diagnosed,treated and taken prevention;the partial patients with dementia can get recovery or remission.

Clinical advances of SPECT rCBF and interventional imaging applied in the diagnosis of dementias

Huazhong University of Science and Technology, Hubei Wuhan 430022, China

Received Date: 2002-01-15

Abstract: Brain perfusion SPECT is a functional and noninvasive neuroimaging technique that allow the investigation of physiological and physiopathological events in the human brain,including cerebral perfusion and function.Interventional rCBF imaging can also evaluate cerebrovascular reserve.In clinically,rCBF imaging play an important role in the diagnosis and differential diagnosis of dementias,especially vascular and Alzheimer's dementia.If etiology of some types of dementias is determined so that it can be early diagnosed,treated and taken prevention;the partial patients with dementia can get recovery or remission.

HTML

Reference (20)

[1]	Ichimyia A. A functional and structural imaging in dementia[J]. Psychiatry Clin Neurosci, 1998, 52(suppl):S223-S225.
[2]	Weinstein HC,Hijdra A,Van Royen EA, et al. SPECT in early-and late-onset Alzheimer's disease[J]. Ann NY Acad Sci, 1991, 640:72-73.
[3]	Brown DR, Hunter R, Wyper DJ, et al. Longitudinal changes in cognitive functional and regional cerebral function in Alzheimer's disease:a SPECT blood flow study[J]. J Psychiatr Res, 1996, 30:109-126.
[4]	Dewan MJ, Gupta S. Toward a definite diagnosis of Alzheimer's disease[J]. Compr Psychiatry, 1992, 33:181-185.
[5]	Holman BL, Johson KA, Gerada B, et al. The scinitigraphic appearance of Alzheimer's disease:a prospective study using technetium-99mTc-HMPAO SPECT[J]. J Nucl Med, 1992, 33:181-185.
[6]	Friedland RP, Kalaria R, Berridge M, et al. Neuroimaging of vessel amyloid in Alzheimer's disease[J]. Ann NY Acad Sci, 1997, 826:242-247.
[7]	Rickkinen PJ, Kuikka J, Soininen H, et al. Tetrahydroaminoacridine modulates technetium -99m labelled ethylene dicysteinate retention in Alzheimer's disease measuerd with SPECT imaging[J]. Neurosci Lett, 1995, 195:53-56.
[8]	Fukuchi K, Hashikawa K, Seike Y, et al. Comparison of iodine-123 iomazenil SPECT and technetium-99m HMPAO SPECT in Alzheimer's disease[J]. J Nucl Med, 1997, 38:467-470.
[9]	Admas RD, Vctor M. Principles of Neurology[M]. 6th ed, New York:McGraw-Hill, 1997. 3-11, 94-113, 1507-1529, 1544-1564.
[10]	Togi H, Chiba K, Sasaki K, et al. Cerebral perfusion partterns in vascular dementia of Binswanger type compared with senile dementia of Alzheimer type:a SPECT study[J]. J Neurol, 1991, 238:365-370.
[11]	Talbot PR, Lioyd JJ, Snowden JS, et al.A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia?[J]. J Neurol Neurosurg Psychiatry, 1998, 64:306-313.
[12]	Seibyl JP, Marek K, Sheff K, et al. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transp orts in health subjects and parkson's patients[J]. J Nucl Med, 1998, 39:1500-1508.
[13]	Tissingh G, Bergmans P, Booij J, et al. Drug-naive patients with Parkson's disease in Hoehn and Yahr stages Ⅰ and Ⅱ show a bilateral decrease in striatal dopamine transporters as revealed by ¹²³I beta-CIT SPECT[J]. J Neurol, 1998, 245:14-20.
[14]	Etchebehere ECSC, Lima MCL, Passos W, et al. Brain SPECT imaging in Huntington's disease before and after therapy with ollanzapine[J]. Arq Neuropsiquiatr, 1999, 57:863-866.
[15]	Bonte FJ, Devous MD, Reisch JS, et al. The effect acetazolamide on regional cerebral blood flow in patients with Alzheimer's disease or stroke as measured by SPECT[J]. Invest Radiol, 1989, 24:99-103.
[16]	Kuwabara Y. Cerebralvascular responsiveness to hypercapnia in Alzheimer's dementia and vascular dementia of binswanger type[J]. Stroke, 1992, 23:594-598.
[17]	Heun R,Kramer G, Knappertz VA, et al. Vasomotor reactivity in dementia of Alzheimer type[J]. Int J Geriatr Psychiatry, 1994, 9:913-918.
[18]	Prohovnik G, Alexander E, Tateraichi TK, et al. Exploring the nature of parietotemporal perfusion deficit in Alzheimer's disease[J]. J Cereb Blood Flow Metab, 1991, 11:179.
[19]	Wolfram HK, Claudia D, Berit M, et al. Changes in local cerebral blood flow by neuroactivation and vasoactivition in patients with imparied congitive function[j]. Eur J Nucl Med, 1996, 23:878-888.
[20]	Pavics L, Grunward F, Barzo P, et al. rCBF SPECT with 99mTc-HMPAO and the acetazolamide test in the evaluation of vascular and Alzheimer's dementia[J]. Eur J Nncl Med, 1999, 26:239-244.

Clinical advances of SPECT rCBF and interventional imaging applied in the diagnosis of dementias

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views

Clinical advances of SPECT rCBF and interventional imaging applied in the diagnosis of dementias

HTML

Catalog