存活素与辐射诱导的凋亡

高洋

Survivin is a intracellular protein that belongs to the inhibitor of apoptosis gene family.Survivin is mostly expressed in fet al tissues and many cancer cell lines,but it is not detected in normal adult tissuses ex-pect for the thymus and testis.It is important to study the molecular mechanisms of surviving both in apopto-sisand and cell division.Furthermore,surviving would be a potential new target for the cancer therapy.

Survivin and radiation-induced apoptosis

The Institute of Combined Injury, The Third Military Medical University, Chongqing 400038, China

Received Date: 2002-12-11

Abstract: Survivin is a intracellular protein that belongs to the inhibitor of apoptosis gene family.Survivin is mostly expressed in fet al tissues and many cancer cell lines,but it is not detected in normal adult tissuses ex-pect for the thymus and testis.It is important to study the molecular mechanisms of surviving both in apopto-sisand and cell division.Furthermore,surviving would be a potential new target for the cancer therapy.

HTML

Reference (15)

[1]	Tamm I, Sausville E, Scudiero DA, et al. IAP-family protein surviving inhibits caspase activity and apoptosis induced by Fas (CD95) bax, caspases and anticancer drugs[J]. Cancer Res, 1998, 58: 5315-5320.
[2]	Takai N, Miyazaki T, Xishida M, et al. Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma[J].Cancer Lett, 2000, 184: 105-116.
[3]	Chantalat L, Dimitrios A and Skoufias DA. Crystal structure of human survivin a bow tie-shaped dimer with two unusual α-helicalextensions[J].Mol Cell,2000,6: 183-189.
[4]	Chen J, Wu W,Ng SC, et al. Down-regulation of surrivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth[J]. Neoplasia,2000,2: 235-241.
[5]	Li F, Altieri DC. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function[J]. Nat Cell Biol, 1999, 1: 461-466.
[6]	Speliotes EK, Uren A, Vaux D, et al. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone[J]. Mol Cell, 2000,6: 211-223.
[7]	Li F and Altieri DC. The cancer antiapoptosis mouse sur-vivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression[J].Cancer Res, 1999,59: 3143-3151.
[8]	Takahashi R, Deveraux Q, Tamm I, et al. A single BIR domain of XIAP sufficient for inhibiting caspases[J]. J Biol Chem, 1998, 273: 7787.
[9]	Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma[J]. Nat Med, 1997,3: 917-921.
[10]	Li F, Ambrosini G, Chu EY, et al. Control of apoptosis and mitotic spindle checkpoint by survivin[J]. Nature, 1998, 396: 580-584.
[11]	Jones G, Jones D, Zhou L, et al. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster[J]. J Biol Chem, 2000, 275: 22157-22165.
[12]	Soengas MS, Mak TW, Lowe SW, et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition[J]. Science, 1999,284: 156-159.
[13]	Watters D, Molecular. Mechanisms of ionizing radiation-induced apoptosis[J]. Immunol Cell Biol, 1999, 77(3): 263-271.
[14]	Brown JM and Wouters BG. Apoptosis, p53, and tumor cell sensi-tivity to anticancer agents[J]. Cancer Res, 1999,59: 1391-1399.
[15]	Tanaka K, Gon G, Iwamoto S, et al. Expression of survivin in its relationship to loss of apoptosis in breast carcinomas[J]. Clin Cancer Res, 2000, 6: 127-134.

Survivin and radiation-induced apoptosis

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views

Survivin and radiation-induced apoptosis

HTML

Catalog