Volume 26 Issue 4
Aug.  2002
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The imaging diagnosis of neuroblastoma

  • Received Date: 2002-02-02
  • Neuroblastoma is the most common extracranial solid tumor,which accounts for 10% of children's tumor.The prognosis is closely related with its clinical grading.And the diagnosis of imaging can provide valuable information for clinical treatment and follow-up.MIBG scintigraphy,somatostatin receptor scintigraphy,radioimmunoscintigraphy,bone scan and PET mainly show the functional status of tumor and its metastases;CT and MRI present more detailed and exact data in anatomy.Each modality has its specified character and works well when combined with each other.
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  • [1] Leung A, Shapiro B, Hattner R, et al. Specificity of radioiodinated MIBG for neural crest tumors in childhood[J]. J Nucl Med, 1997, 38(9):1352-1357.
    [2] Hoefnagel CA. Metaiodobenzylguanidine and somatostatin in oncology:role in the management of neural crest tumors[J]. Eur J Nucl Med, 1994, 21(6):561-581.
    [3] Brans B, Laureys G, Scheffhout V, et al. Activity of iodine-123 metaiodobenzylguanidine in childhood neuroblastoma:lack of relation to tumor differentiation in vivo[J]. Eur J Nucl Med, 1998, 25(2):144-149.
    [4] Kropp J, Hofmann M, Bihl H. Comparison of MIBG and pentetreotide scintigraphy in children with neuroblastoma.:Is the expression of somatostatin receptors a prognostic factor?[J]. Anticancer Res, 1997, 17:1583-1588.
    [5] Briganti V, Sestini R, Orland C, et al. Imaging of somatostatin receptors by indium-111-pentetreotide correlates with quantitative determination of somatostatin receptor type 2 gene expression in neuroblastoma tumors[J]. Clin Cancer Res, 1997, 3:2385-2391.
    [6] Yeh SDJ, Larson SM, Butch L, et al. Radioimmunodetection of neuroblastoma with iodine-131-3F8:Correlation with biopsy, iodine-131-metaiodobenzylgnanidine and standard diagnostic modalities[J]. J Nucl Med, 1991, 32(5):769-776.
    [7] Hoefnagel CA, Rutgers M, Buitcnhnis CKM, et al. A comparison of targeting of neuroblastoma with MIBG and anti L1-CAM antibody mAb ehCE7:therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblasroma patients[J]. Eur J Nucl Med, 2001, 28(3):359-368.
    [8] Shulkin BL, Hutchinson RJ, Castle VP, et al. Neuroblastoma:positron emission tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose compared with metaiodobenzylg uanidine scintigraphy[J]. Radiology, 1996,199(3):743-750.
    [9] Kushner BH, Yeung HWD, Larson SM, et al. Extending positron emission tomography scan utility to high-risk neuroblastoma:fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients[J]. J Clin Oncol, 2001, 19(14):3397-3405.
    [10] Shulkin BL, Wieland DM, Baro ME, et al. PET hydroxyephedrine imaging of neuroblastoma[J]. J Nncl Med, 1996, 37(1):16-21.
    [11] Albregts AE, Cohen MD, Galliani CA. Neuroblastoma invading the kidney[J]. J Pediatr Surg, 1994, 29(7):930-933.
    [12] Cassady C, Winters WD. Bilateral cystic neuroblastoma:imaging features and differential diagnoses[J]. Pediatr Radiol, 1997, 27:758-759.
    [13] Tanabe M, Ohnuma N, Iwai J, et al. Bone marrow metastasis of neuroblastoma analysed by MRI and its influence on prognosis[J]. Med Pediatr Oncol, 1995, 24:292-299.
    [14] Sofka CM, Semelka RC, Kelekis NL, et al. Magnetic resonance imaging of neuroblastoma using current techniques[J]. Magn Resort Imag, 1999, 17(2):193-198.
    [15] Hugosson C, Nyman R, Jorulf H, et al. Imaging of abdominal neuroblastoma in children[J]. Acta Radiologica, 1999, 40:534-542.
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The imaging diagnosis of neuroblastoma

  • Imaging Diagnostic Center of Shanghai Second Medical University Affiliated Xinhua Hospital Shanghai Children's Medical Center, Shanghai 200127, China

Abstract: Neuroblastoma is the most common extracranial solid tumor,which accounts for 10% of children's tumor.The prognosis is closely related with its clinical grading.And the diagnosis of imaging can provide valuable information for clinical treatment and follow-up.MIBG scintigraphy,somatostatin receptor scintigraphy,radioimmunoscintigraphy,bone scan and PET mainly show the functional status of tumor and its metastases;CT and MRI present more detailed and exact data in anatomy.Each modality has its specified character and works well when combined with each other.

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