131I therapy of thyroid cancer after surgery
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Received Date:
2002-07-06
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Abstract
The classic therapy of metastatic well differented thyroid cancer is administration of 131I after subtotal thy-roectomy.The sodium/iodine symporter (NIS)mediates the active transport of iodine into thyroid cells,while the thy-roperoxidase (TPO)suppresses the out-flow of iodine from thyroid cells.As a result,a new potential approach has been develepted with co-transfection of NIS and TPO genes to thyroid cancer cells,which can enhance the results of radioio-dine.Retinoide is also useful to 131I therapy for it can induce non-differented thyroid cancer cells to well-differnted cells to increase radioiodine uptake.
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