Volume 26 Issue 4
Aug.  2002
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Article Navigation >  Int J Radiat Med Nucl Med  > 2002,  26 > 4: (180-182)  

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G2 phase arrest of cell cycle induced by ionizing radiation

  • MH Radiobiology Research Unit, Jilin University, Jilin Changchun 130021, China

  • Received Date: 2002-05-28
  • The exposure of mammalian cells to X rays results in the prolongation of the cell cycle,including the delay or the arrest in G1,S and G2 phase.The major function of G1 arrest may be to eliminate the cells containing DNA damage and only occurs in the cells with wild type p53 function whereas G2 arrest following ionizing radiation has been shown to be important in protecting the cells from death and occurs in all cells regardless of p53 status.So the study on G2 phase arrest of the cell cycle induced by ionizing radiation has currently become a focus at radiobiological fields.
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  • [1] Taylor WR, Stark GR. Regulation of the G2/M transition by p53[J]. Oncogene, 2001, 20(15):1803-1815.
    [2] Taylor WR, Deprimo SE, Agarwal A, et al. Mechanisms of G2 arrest in response to overexpression of p53[J]. Mol Biol Cell, 1999, 10(11):3607-3622.
    [3] Siu WY, Yam CH, Pooh RY. G1 versus G2 cell cycle arrest after adriamycin induced damage in mouse Swiss3T3 cell[J]. FEBS Lett, 1999, 461(3):299-305.
    [4] Flatt PM, Tang LJ, Scatona CD, et al. p53 regulation of G2 checkpoint is retinoblastoma protein dependent[J]. Mol Cell Biol, 2000, 20(12):4210-4223.
    [5] Zhan Q, Antinore MJ, Wang XW, et al. Association with cdc2 and inhibition of cdc2/cyclin B1 kinase activity by the p53 regulated protein gadd45[J]. Oncogene, 1999, 18(18):2892-2895.
    [6] Jin S, Antinore MJ, Lung FD, et al. The GADD45 inhibition of cdc2 kinase correlates with GADD45 mediated growth suppression[J]. J Biol Chem, 2000, 275(22):16602-16608.
    [7] Yang Q, Manicone A, Corusen JD, et al. Identification of a functional domain in a GADD45 mediated G2/M checkpoint[J]. J Biol Chem, 2000, 275(47):36892-36898.
    [8] Wang XW, Zhan Q, Coursen JO, et al. GADD45 induction of a G2/M cell cycle checkpoint[J]. Proc Nat Acad Sci USA, 1999, 96(7):3706-3711.
    [9] Samuel T, Weber HO, Ranch P, et al. The G2/M regulator 14-3-3 sigma prevents apoptosis through sequestration of Bax[J]. J Biol Chem, 2001, 276(48):45201-45206.
    [10] Chan TA, Hermeding H, Lengauer C, et al. 14-3-3 sigma is required to prevent mitotic catastrphe after DNA damage[J]. Nature, 1999, 401(6753):616-620.
    [11] Bulavin DV, Amundson SA, Fomace AJ. P38 and Chkl kinase:different conductors for the G2/M checkpoint symphony[J]. Curr Opin Genet Dev, 2002, 12(1):92-97.
    [12] Athar M, Kim AL, Ahmad N, et al. Mechanism of ultraviolet B induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53[J]. Biochem Biophys Res Commun, 2000, 277(1):107-111.
    [13] Goldstone S, Pavey S, Forrest A, et al. Cdc 25 dependent activation of cyclin A/cdk2 is blocked in G2 phrase arrested cells independently of ATM/ATR[J]. Oncogene, 2001, 20(8):921-932.
    [14] Hirao A, Kong YY, Matsuoka S, et al. DNA damage induced activation of p53 by the checkpoint kinase chk2[J]. Science, 2000, 287(5459):1824-1827.
    [15] Teyssier F, Bay JO, Dionet C, et al. Cell cycle regulation agents exposure to ionizing radiation[J]. Bull Cancer, 1999, 86(4):345-357.
    [16] Deplaque G, Ceraline J, Becherel MC, et al. Caffeine and G2/M block override:a concept resulting from a misleading cell kinetic delay independent of functional p53[J]. Int J Cancer, 2001, 94(3):363-369.
    [17] Luo Y, Rockow SK, Joseph MK, et al. Abrogation go G2 checkpoint specifically sensitize p53 defective cells to cancer chemthrapeutic agents[J]. Anticancer Res, 2001, 21(1A):23-28.
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G2 phase arrest of cell cycle induced by ionizing radiation

  • MH Radiobiology Research Unit, Jilin University, Jilin Changchun 130021, China
  • Received Date: 2002-05-28

Abstract: The exposure of mammalian cells to X rays results in the prolongation of the cell cycle,including the delay or the arrest in G1,S and G2 phase.The major function of G1 arrest may be to eliminate the cells containing DNA damage and only occurs in the cells with wild type p53 function whereas G2 arrest following ionizing radiation has been shown to be important in protecting the cells from death and occurs in all cells regardless of p53 status.So the study on G2 phase arrest of the cell cycle induced by ionizing radiation has currently become a focus at radiobiological fields.

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