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Apr.  2001
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Signal transduction of ataxia-telangiectasia

  • Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2000-01-20
  • The genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency, progressive cerebellar ataxia, gonadal abnormalities, radiosensitivity, and cancer predisposition. In this paper, the signal transduction of AT are reviewed, including ATM (AT mutated) gene and clinicalsymptoms, some transoription factors in the signaling pathway induced by ionizing radiation, cell cycle checkpoint defects, durative oxidative stress and cell apoptosis.
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    [2] Gang C,Eva Y,Lee HP.The product of the ATM Gene is a 370 kda Nuclear Phosphoprotein[J].J Biol Chem,1996,271:33693-33697.
    [3] Crawford TO.Ataxia telangiectasia[J].Semin Pediatr Neurol,1998,5(4):287-294.
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    [9] Khanna KK,Keating KE,Kozlov S,et al.ATM associates with and phosphorylates p53:mapping the region of interaction[J].Nat Genet,1998,20(4):398-400.
    [10] BarlowC,Brown KD,Deng CX,et al.Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways[J].Nat Genet,1997,17(4):453-456.
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    [14] Zhang N,Chen P,Gatei M,et al.An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells[J].Oncogene,1998,17(7):811-818.
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    [19] Shafman T,Khanna KK,Kedar P,et al.Interaction between ATM protein and c-Ab1 in response to DNA damage[J].Nature,1997,387(6632):520-523.
    [20] Baskaran R,Wood LD,Whitaker LL,et al.Ataxia telangiectasia mutant protein activates c-Ab1 tyrosine kinase in response to ionizing radiation[J].Nature,1997,387(6632):516-519.
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Signal transduction of ataxia-telangiectasia

  • Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2000-01-20

Abstract: The genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency, progressive cerebellar ataxia, gonadal abnormalities, radiosensitivity, and cancer predisposition. In this paper, the signal transduction of AT are reviewed, including ATM (AT mutated) gene and clinicalsymptoms, some transoription factors in the signaling pathway induced by ionizing radiation, cell cycle checkpoint defects, durative oxidative stress and cell apoptosis.

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